{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:16:10Z","timestamp":1790115370236,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,12,30]],"date-time":"2011-12-30T00:00:00Z","timestamp":1325203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>ABSTRACT<\/jats:title><\/jats:sec><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Botulinum toxin (BoNT) treatment relieves focal arm spasticity after stroke, likely acting at several hierarchical levels of the motor system. The central correlate of BoNT\u2010induced spasticity relief may be detected using repeated functional MRI (fMRI) during motor task.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Five patients (4 males, 1 female, mean age 67 years) with hemiparesis and distal arm spasticity after chronic ischemic stroke were studied. FMRI was performed while moving the paretic hand in three sessions: before and 4 and 11 weeks after BoNT treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Arm spasticity significantly decreased following BoNT treatment across the group (mean modified Ashworth scale change .6). FMRI prior to BoNT treatment showed extensive bilateral active networks, whereas post\u2010BoNT activation was limited to midline and contralateral sensorimotor cortices, and the third examination, when the toxin effect has worn off, again showed extensive activation similar to pre\u2010BoNT examination. Post\u2010BoNT session 2 compared to sessions 1 and 3 demonstrated a significantly less activation in contralateral frontoparietal areas including inferior frontal, postcentral, and middle frontal gyri as well as transient crossed cerebellar activation.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Relief of post\u2010stroke arm spasticity may be associated with changes at several hierarchical levels of the cortical sensorimotor system, including the prefrontal cortex.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1552-6569.2011.00682.x","type":"journal-article","created":{"date-parts":[[2011,12,30]],"date-time":"2011-12-30T18:02:35Z","timestamp":1325268155000},"page":"337-344","source":"Crossref","is-referenced-by-count":27,"title":["Cortical Activation Changes in Patients Suffering from Post\u2010Stroke Arm Spasticity and Treated with Botulinum Toxin A"],"prefix":"10.1111","volume":"23","author":[{"given":"Zuzana","family":"Tom\u00e1\u0161ov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Hlu\u0161t\u00edk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Kr\u00e1l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Otruba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Herzig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alois","family":"Krobot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Ka\u0148ovsk\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,30]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"12","volume-title":"Upper Motor Neuron Syndrome and Spasticity","author":"Sheean G","year":"2001"},{"key":"e_1_2_7_3_2","first-page":"401","article-title":"Spasticity as an adaptation to pyramidal tract injury","volume":"47","author":"Burke D","year":"1988","journal-title":"Adv Neurol"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.12.1303"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/09638288809164103"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.159657"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0375-08.2008"},{"key":"e_1_2_7_8_2","volume-title":"Spasticita: mechanismy, diagnostika a l\u00e9\u010dba","author":"Ka\u0148ovsk\u00fd P","year":"2004"},{"key":"e_1_2_7_9_2","first-page":"123","article-title":"Long\u2010term remission of cervical dystonia induced by treatment with botulotoxin A\u2014Signal of the possible effect on the central dystonic mechanism? 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