{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T06:48:19Z","timestamp":1698734899452},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T00:00:00Z","timestamp":1337558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>To evaluate the proton magnetic resonance (MR) spectroscopy (<jats:sup>1<\/jats:sup>H MRS) changes in carriers of a novel octapeptide repeat insertion in the prion protein gene (PRNP) and family history of frontotemporal dementia with ataxia. Four at\u2010risk mutation carriers and 13 controls were compared using single voxel, short TE, <jats:sup>1<\/jats:sup>H MRS from the posterior cingulate gyrus. The mutation carriers had an increased choline\/creatine, <jats:italic>P<\/jats:italic>= .003 and increased myoinositol\/creatine ratio, <jats:italic>P<\/jats:italic>= .003. <jats:sup>1<\/jats:sup>H MRS identified differences in markers of glial activity and choline metabolism in pre\u2010 and early\u2010symptomatic carriers of a novel PRNP gene octapeptide insertion. These findings expand the possible diagnostic utility of <jats:sup>1<\/jats:sup>H MRS in familial prion disorders.<\/jats:p>","DOI":"10.1111\/j.1552-6569.2012.00717.x","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T18:14:46Z","timestamp":1337624086000},"page":"409-413","source":"Crossref","is-referenced-by-count":1,"title":["MRS in Early and Presymptomatic Carriers of a Novel Octapeptide Repeat Insertion in the Prion Protein Gene"],"prefix":"10.1111","volume":"23","author":[{"given":"Eric M","family":"McDade","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley F.","family":"Boeve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A","family":"Fields","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Rademakers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt C.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BSc, David S.","family":"Knopman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald C.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Clifford R.","family":"Jack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kejal","family":"Kantarci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000201237.05869.df"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f073c7"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-006-0068-1"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp210"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910310404"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000141849.21256.AC"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1301"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.187"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-005-0020-1"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-005-0090-4"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002340000371"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/crad.2002.1080"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283427da7"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp135"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp157"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.31.060407.125606"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200108080-00007"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.2.210"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2481071590"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1552-6569.2012.00717.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1552-6569.2012.00717.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T07:07:10Z","timestamp":1698649630000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1552-6569.2012.00717.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,21]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/j.1552-6569.2012.00717.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1552-6569.2012.00717.x","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,21]]}}}