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We aimed to visualize CMIs, which remain invisible on conventional MRI, using double inversion recovery (DIR) and 3\u2010dimensional fluid attenuated inversion recovery (3D\u2010FLAIR) on 3\u2010Tesla MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We prospectively performed DIR and 3D\u2010FLAIR images in 70 subjects with Alzheimer disease (AD; <jats:italic>n<\/jats:italic>\u2003=\u200347), mild cognitive impairment (<jats:italic>n<\/jats:italic>\u2003=\u200314), AD with cerebrovascular disease (CVD; <jats:italic>n<\/jats:italic>\u2003=\u20033), vascular dementia (VaD; <jats:italic>n<\/jats:italic>\u2003=\u20032), CAA\u2010associated intracerebral hemorrhage (ICH;\u2003<jats:italic>n<\/jats:italic>\u2003= 2) and one each of normal pressure hydrocephalus and dementia with Lewy bodies (DLB). Susceptibility\u2010weighted imaging (SWI) was performed to detect cerebral microbleeds (CMBs).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Nine subjects (five of AD and one each of AD with CVD, ICH, VaD, and DLB) had small intracortical high signal lesions on both DIR and 3D\u2010FLAIR images. All the nine subjects accompanied multiple lobar CMBs. These intracortical lesions were located in close proximity to CMBs, and were suggested to be CMIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>DIR and 3D\u2010FLAIR images may open a way to visualize CMIs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1552-6569.2012.00722.x","type":"journal-article","created":{"date-parts":[[2012,5,18]],"date-time":"2012-05-18T15:27:45Z","timestamp":1337354865000},"page":"28-32","source":"Crossref","is-referenced-by-count":58,"title":["In vivo Detection of Cortical Microinfarcts on Ultrahigh\u2010Field MRI"],"prefix":"10.1111","volume":"23","author":[{"given":"Yuichiro","family":"Ii","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Kida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Shindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Tomimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04794.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000110791.51378.4E"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000257094.10655.9a"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000024523.82311.77"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32832d2e6a"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1550"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007020200068"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.11.1629"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.593657"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.6.790"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0615-z"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.204685"},{"key":"e_1_2_6_14_2","first-page":"54","article-title":"Double inversion recovery brain imaging at 3T: diagnostic value in the detection of multiple sclerosis lesions","volume":"28","author":"Wattjes MP","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0620-5"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22115"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-009-1705-y"},{"key":"e_1_2_6_18_2","unstructured":"American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders\u2010IV. 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