{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T10:32:46Z","timestamp":1778236366863,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T00:00:00Z","timestamp":1356652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Although metastatic skull lesions of neuroblastoma are not uncommon, brain involvement is infrequent and prompt diagnosis is of utmost importance in such cases. Previous studies have shown that Meta\u2010Iodo\u2010Benzyl\u2010Guanidine (MIBG) scans were not always reliable in detecting central nervous system metastases, however most published reports referred to the Iodine\u2010131 (<jats:sup>131<\/jats:sup>I)\u2010MIBG scans. Herein, we report an intraventricular metastasis of neuroblastoma diagnosed using an Iodine\u2010123 (<jats:sup>123<\/jats:sup>I)\u2010MIBG scan, which is increasingly being used in clinical practice and reported as a more accurate method for detecting metastatic lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>CASE DESCRIPTION<\/jats:title><jats:p>An unusual case of metastatic neuroblastoma to the left lateral ventricle of the brain is presented. Planar <jats:sup>123<\/jats:sup>I\u2010MIBG scintigraphy showed faint tracer activity close to the midline without asymmetric extensions or abnormal activity in the skull bones. A subsequent brain MR scan revealed an enhancing mass within the left frontal horn consistent with a metastatic lesion. The patient underwent tumor resection with pathology showing neuroblastoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Our case shows that <jats:sup>123<\/jats:sup>I\u2010MIBG scintigraphy can be useful in detecting intraventricular brain metastases of neuroblastoma. Although the <jats:sup>123<\/jats:sup>I\u2010MIBG scintigraphy has been reported to have a significantly superior sensitivity in monitoring asymptomatic patients with neuroblastoma compared with <jats:sup>131<\/jats:sup>I\u2010MIBG scans, bone marrow histology, bone scan, CT, and urinary catecholamine levels, further studies may be necessary to evaluate its sensitivity in detecting brain lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1552-6569.2012.00754.x","type":"journal-article","created":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T16:02:33Z","timestamp":1356710553000},"page":"202-204","source":"Crossref","is-referenced-by-count":19,"title":["Neuroblastoma with a Solitary Intraventricular Brain Metastasis Visualized on I\u2010123 MIBG Scan"],"prefix":"10.1111","volume":"24","author":[{"given":"Ion","family":"Codreanu","sequence":"first","affiliation":[{"name":"Department of Radiology The Children's Hospital of Philadelphia University of Pennsylvania School of Medicine Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin A.","family":"Dasanu","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology Saint Francis Hospital and Medical Center Hartford CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongming","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Children's Hospital of Philadelphia University of Pennsylvania School of Medicine Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,28]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"1172","article-title":"Neuroblastoma: a disease requiring a multitude of imaging studies","volume":"45","author":"Kushner BH","year":"2004","journal-title":"J Nucl Med"},{"key":"e_1_2_4_3_1","first-page":"411","article-title":"Therapeutic nuclear medicine in pediatric malignancy","volume":"54","author":"Schmidt M","year":"2010","journal-title":"Q J Nucl Med Mol Imaging"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02011102"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11448"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-199101000-00002"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0883-2897(90)90172-W"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199411000-00011"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199807000-00009"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.6107"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.3203"},{"key":"e_1_2_4_12_1","first-page":"220","article-title":"[Follow up control of stage IV neuroblastoma: 123I\u2010MIBG scintigraphy, bone scintigraphy and catecholamine metabolites]","volume":"35","author":"Kohnert K","year":"1996","journal-title":"Nuklearmedizin"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19911101)68:9<1999::AID-CNCR2820680926>3.0.CO;2-0"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1552-6569.2012.00754.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1552-6569.2012.00754.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T20:40:51Z","timestamp":1696279251000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1552-6569.2012.00754.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,28]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/j.1552-6569.2012.00754.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1552-6569.2012.00754.x","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,28]]}}}