{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:30:14Z","timestamp":1790908214266,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T00:00:00Z","timestamp":1356652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Recent studies suggest that alterations in the cerebrospinal venous system may play a role in multiple sclerosis (MS) and that chronic cerebrospinal venous insufficiency correlates with clinical features of MS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>To evaluate the vascularization of optic nerve (ONr) and measure ONe thickness by color Doppler ultrasonography in MS patients with and without previous optic neuritis (ONe).<\/jats:p><\/jats:sec><jats:sec><jats:title>SUBJECTS AND METHODS<\/jats:title><jats:p>We assessed flow variables in the ophthalmic artery, central retinal artery, and central retinal vein and measured the diameter of ONe in 46 relapsing\u2010remitting MS patients and 37 healthy controls (HC). Twenty\u2010two MS patients had previous ONe and 24 MS patients had not. Patients with acute ONe were not included. We examined and compared 63 unaffected and 29 affected eyes of MS patients with 74 control eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Regarding flow variables, we did not find any significant difference between HC, MS affected, and unaffected eyes. Comparing ONr diameters, we found a progressive significant thinning of the ONr from HC to MS patients without and with past ONe.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>We found no significant alteration in the arterial\u2010venous vascularization of both affected and unaffected ONr compared with HC. We demonstrated the possibility to detect ONr atrophy in MS patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1552-6569.2012.00758.x","type":"journal-article","created":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T16:03:00Z","timestamp":1356710580000},"page":"273-277","source":"Crossref","is-referenced-by-count":16,"title":["Optic Nerve and its Arterial\u2010Venous Vascularization: An Ultrasonologic Study in Multiple Sclerosis Patients and Healthy Controls"],"prefix":"10.1111","volume":"24","author":[{"given":"Nicola","family":"Carraro","sequence":"first","affiliation":[{"name":"Department of Medical Sciences Clinical Neurology\u2010Stroke Unit, University Hospital, University of Trieste  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Servillo","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Clinical Neurology\u2010Stroke Unit, University Hospital, University of Trieste  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittoria","family":"Maria Sarra","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Clinical Neurology\u2010Stroke Unit, University Hospital, University of Trieste  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Bignamini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences \u201cPiero Pratesi\u201d School of Specialization in Hospital Pharmacy, University of Milan  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Pizzolato","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Clinical Neurology\u2010Stroke Unit, University Hospital, University of Trieste  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marino","family":"Zorzon","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Clinical Neurology\u2010Stroke Unit, University Hospital, University of Trieste  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060070096025"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.011"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70105-3"},{"issue":"2","key":"e_1_2_5_5_1","first-page":"S62","article-title":"Endothelin and nitric oxide levels in cerebrospinal fluid of patients with multiple sclerosis","volume":"6","author":"Speciale L","year":"2000","journal-title":"J Neurovirol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000073079"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000069085"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.11.027"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.157164"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22085"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22228"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318230a149"},{"key":"e_1_2_5_13_1","first-page":"183","article-title":"Hemodynamic patterns of chronic crebrospinal venous insufficiency in multiple sclerosis. 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