{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:09:32Z","timestamp":1761059372709},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T00:00:00Z","timestamp":1343692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:sec><jats:label \/><jats:p>ACADEMIC EMERGENCY MEDICINE 2012; 19:901\u2013907 \u00a9 2012 by the Society for Academic Emergency Medicine<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> Inferior vena cava ultrasound (IVC\u2010US) assessment has been proposed as a noninvasive method of assessing volume status. Current literature is divided on its ability to do so. The primary objective was to compare IVC\u2010US changes in healthy fasting subjects randomized to either 10\u2003or 30\u2003mL\/kg of intravenous (IV) fluid administration versus a control group that received only 2\u2003mL\/kg.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> This was a prospective randomized double\u2010blinded trial set in emergency department (ED) clinical care rooms. Volunteer subjects with no history of cardiac disease or hypertension fasted for 12\u2003hours. Subjects were randomly assigned to receive IV 0.9% saline bolus of 2\u2003(control group), 10, or 30\u2003mL\/kg over 30\u2003minutes. IVC\u2010US was performed before and 15\u2003minutes after each fluid bolus.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Forty\u2010two fasting subjects were enrolled. Analysis of variance (ANOVA) comparison showed that IVC\u2010US was unable to detect any significant difference between the control group and those given either 10\u2003or 30\u2003mL\/kg fluid, whether using maximum or minimum IVC diameter or caval index (IVC\u2010CI). The groups receiving 10\u2003and 30\u2003mL\/kg each had a statistically significant change in IVC\u2010CI; however, the 30\u2003mL\/kg group had no significant change in either of the mean IVC diameters.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Overall, there were statistically significant differences in mean IVC\u2010US measurements before and after fluid loading, but not between groups. Fasting asymptomatic subjects had a wide intersubject variation in both baseline IVC\u2010US measurements and fluid\u2010related changes. The degree of IVC\u2010US change in association with graded acute volume loading was not predictably proportional between our subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1553-2712.2012.01416.x","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T19:49:08Z","timestamp":1343764148000},"page":"901-907","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Effect of Weight\u2010based Volume Loading on the Inferior Vena Cava in Fasting Subjects: A Prospective Randomized Double\u2010blinded Trial"],"prefix":"10.1111","volume":"19","author":[{"given":"Anthony J.","family":"Weekes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret R.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary P.","family":"Kahler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald E.","family":"Stader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale P.","family":"Quirke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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