{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T14:45:32Z","timestamp":1699022732448},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,8,28]],"date-time":"2007-08-28T00:00:00Z","timestamp":1188259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> A fatal case involving mepivacaine\u2010induced epidural anesthesia is described. The pathological findings were typical of cardiac shock from ischemic origin. Cerebrospinal fluid (CSF) was obtained several hours after death and mepivacaine was identified by gas chromatography\u2010mass spectrometry (GC\u2010MS). Its concentration was determined by high performance liquid chromatography with diode array detection (HPLC\u2013DAD). Extraction from CSF was performed by deproteinization with acetonitrile. The mepivacaine concentration in the sample was 264\u2003\u03bcg\/mL. Concentrations of mepivacaine in CSF following epidural anesthesia are not reported in literature to our knowledge. This is the first reported case of death in which the mepivacaine concentration in CSF has been determined.<\/jats:p>","DOI":"10.1111\/j.1556-4029.2007.00526.x","type":"journal-article","created":{"date-parts":[[2007,8,31]],"date-time":"2007-08-31T13:14:02Z","timestamp":1188566042000},"page":"1223-1224","source":"Crossref","is-referenced-by-count":3,"title":["HPLC\u2013DAD Determination of Mepivacaine in Cerebrospinal Fluid from a Fatal Case"],"prefix":"10.1111","volume":"52","author":[{"given":"Maria","family":"Nieddu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianpiero","family":"Boatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Serra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Soro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Lorenzoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Lubinu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,28]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Clarke\u2019s analysis of drugs and poisons in pharmaceuticals, body fluids and postmortem material","author":"Moffat AC","year":"2004"},{"key":"e_1_2_5_3_2","first-page":"103","article-title":"Distribution of drugs in various tissues in a brain dead man","volume":"90","author":"Narumi J","year":"1991","journal-title":"Forensic Sci Int"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00769-002-0516-5"},{"key":"e_1_2_5_5_2","first-page":"533","article-title":"Trends in quality in the analytical laboratory. II. Analytical method validation and quality assurance","volume":"23","author":"Taveniers I","year":"2004","journal-title":"Trend Analyt Chem"},{"key":"e_1_2_5_6_2","volume-title":"Validation of compendial methods","author":"United States Pharmacopoeia 24 NF 19","year":"2000"}],"container-title":["Journal of Forensic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1556-4029.2007.00526.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1556-4029.2007.00526.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T22:19:40Z","timestamp":1697062780000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1556-4029.2007.00526.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,28]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1111\/j.1556-4029.2007.00526.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1556-4029.2007.00526.x","archive":["Portico"],"relation":{},"ISSN":["0022-1198","1556-4029"],"issn-type":[{"value":"0022-1198","type":"print"},{"value":"1556-4029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,28]]}}}