{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T13:41:47Z","timestamp":1745761307230},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T00:00:00Z","timestamp":1345766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antidepressant discontinuation syndrome (<jats:styled-content style=\"fixed-case\">ADS<\/jats:styled-content>) occurs after abrupt discontinuation of an antidepressant medication. A 23\u2010year\u2010old man with right hippocampal agenesis demonstrated sexual crime (hypersexuality) since the age of eight and had been successfully treated with carbamazepine since the age of 13. He had required increased doses of paroxetine and carbamazepine owing to the development of an unstable affect after quitting his job. He abruptly stopped taking his medication for 3\u00a0days and his criminal behaviors re\u2010emerged. We examined changes in brain structure and activity before and after medication cessation, using <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> and functional <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content>). The image of a girl in a swimsuit increased activity in the thalamus only after medication discontinuation. The alteration in thalamic activity might induce hypersexuality. We conclude that a primary hypersexuality had been suppressed with carbamazepine and paroxetine treatment, and the discontinuation of the medication caused the hypersexuality.<\/jats:p>","DOI":"10.1111\/j.1556-4029.2012.02248.x","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T14:56:53Z","timestamp":1345820213000},"page":"255-258","source":"Crossref","is-referenced-by-count":4,"title":["Hippocampal Agenesis in an Individual who Engaged in Violent Criminal Behaviors After Discontinuing <scp>C<\/scp>arbamazepine and <scp>P<\/scp>aroxetine Treatment"],"prefix":"10.1111","volume":"58","author":[{"given":"Hiroaki","family":"Hanada","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Oita University Faculty of Medicine Hasama\u2010Machi Oita 879\u20105593 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jotaro","family":"Akiyoshi","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Oita 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