{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:02:29Z","timestamp":1787014949828,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T00:00:00Z","timestamp":1348099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The stability of two benzisoxazole antipsychotics was determined\n                    <jats:italic>in vitro<\/jats:italic>\n                    in decomposing porcine blood inoculated with bacteria, utilizing a high\u2010performance liquid chromatography with ultraviolet and fluorescence detection method for drug quantitation. Stability experiments for risperidone and paliperidone were conducted at 7, 20 and 37\u00b0C for 4\u00a0days using sterile and bacterially inoculated porcine blood. The drugs were stable in sterile blood at each temperature and in inoculated blood at 7\u00b0C, but degraded significantly in inoculated blood at 20 and 37\u00b0C. Complete loss occurred within 2\u00a0days when incubated at 37\u00b0C. The benzisoxazole\u2010cleaved degradation products for both drugs were identified as 2\u2010hydroxybenzoyl\u2010risperidone and 2\u2010hydroxybenzoyl\u2010paliperidone utilizing liquid chromatography quadrupole\u2010time\u2010of\u2010flight mass spectrometry and accurate mass measurements. The degradation products have been found in postmortem case studies, including one case where risperidone and paliperidone were not detected, indicating complete conversion can occur\n                    <jats:italic>in situ<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/j.1556-4029.2012.02280.x","type":"journal-article","created":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T11:31:53Z","timestamp":1348140713000},"page":"90-100","source":"Crossref","is-referenced-by-count":36,"title":["Bacterial Degradation of Risperidone and Paliperidone in Decomposing Blood"],"prefix":"10.1111","volume":"58","author":[{"given":"Danielle M.","family":"Butzbach","sequence":"first","affiliation":[{"name":"School of Chemical and Physical Sciences Flinders University Bedford Park SA 5042 Australia"},{"name":"Forensic Science South Australia 21 Divett Place Adelaide SA 5000 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Stockham","sequence":"additional","affiliation":[{"name":"School of Chemical and Physical Sciences Flinders University Bedford Park SA 5042 Australia"},{"name":"Forensic Science South Australia 21 Divett Place Adelaide SA 5000 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilton J.","family":"Kobus","sequence":"additional","affiliation":[{"name":"School of Chemical and Physical Sciences Flinders University Bedford Park SA 5042 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Noel Sims","sequence":"additional","affiliation":[{"name":"School of Chemical and Physical Sciences Flinders University Bedford Park SA 5042 Australia"},{"name":"Forensic Science South Australia 21 Divett Place Adelaide SA 5000 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger W.","family":"Byard","sequence":"additional","affiliation":[{"name":"Forensic Science South Australia 21 Divett Place Adelaide SA 5000 Australia"},{"name":"Discipline of Anatomy and Pathology The University of Adelaide Adelaide SA 5005 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Lokan","sequence":"additional","affiliation":[{"name":"Forensic Science South Australia 21 Divett Place Adelaide SA 5000 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Stewart Walker","sequence":"additional","affiliation":[{"name":"School of Chemical and Physical Sciences Flinders University Bedford Park SA 5042 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12024-007-0025-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jflm.2010.10.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12024-009-9130-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2007.04.224"},{"issue":"4","key":"e_1_2_6_6_1","first-page":"311","article-title":"Stability of fluoxetine in stored plasma, aqueous and methanolic solutions determined by HPLC with UV detection","volume":"56","author":"Binsumait IA","year":"2001","journal-title":"Die Pharm"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/23.6.535"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1520\/JFS13791J"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0964-8305(99)00066-9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9432(74)90102-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-7368(84)72350-4"},{"key":"e_1_2_6_12_1","volume-title":"Australian public assessment report for paliperidone","author":"Therapeutic Goods Administration","year":"2009"},{"key":"e_1_2_6_13_1","volume-title":"Australian public assessment report for risperidone","author":"Therapeutic Goods Administration","year":"2010"},{"key":"e_1_2_6_14_1","volume-title":"eBS Australian Register of Therapeutic Goods Medicines","author":"Therapeutic Goods Administration","year":"2011"},{"key":"e_1_2_6_15_1","unstructured":"eMIMS [database on computer disc]. Version 5.01.0106.St Leonards NSW:CMPMedica Australia Pty Ltd 2011."},{"key":"e_1_2_6_16_1","volume-title":"Schedule of pharmaceutical benefits","author":"Department of Health and Aging","year":"2008"},{"issue":"7","key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1177\/106002809703100712","article-title":"Fatal cardiac event following initiation of risperidone therapy","volume":"31","author":"Ravin DS","year":"1997","journal-title":"Ann Pharmacother"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/20.3.202"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C228"},{"key":"e_1_2_6_20_1","unstructured":"ButzbachDM ByardRW KobusH SimsDN StockhamPC LokanRJ et\u00a0al.Stability of selected prescription drugs during decomposition. Proceedings of the 48th Annual Meeting of The International Association of Forensic Toxicologists; 2010 Aug 29\u2013Sept 2; Bonn Germany;http:\/\/www.tiaft.org\/(accessed September 3 2012)."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.018275"},{"issue":"6","key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/S0090-9556(25)08211-X","article-title":"Absorption, metabolism, and excretion of risperidone in humans","volume":"21","author":"Mannens G","year":"1993","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1997.tb06790.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-008-2498-6"},{"key":"e_1_2_6_25_1","volume-title":"Installation guide: Agilent 6500 series quadrupole time\u2010of\u2010flight LC\/MS system","author":"Agilent Technologies Inc","year":"2007"},{"key":"e_1_2_6_26_1","volume-title":"Acetic anhydride product specification","author":"Supelco Technical Service Department","year":"1997"},{"key":"e_1_2_6_27_1","volume-title":"Organic electronic spectral data: 1953\u20131955","author":"Ungnade HE","year":"1960"},{"issue":"1","key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0090-9556(25)08286-8","article-title":"The metabolism and excretion of risperidone after oral administration in rats and dogs","volume":"22","author":"Meuldermans W","year":"1994","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_6_29_1","volume-title":"Postmortem change in human and animal remains: a systematic approach","author":"Micozzi MS","year":"1991"}],"container-title":["Journal of Forensic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1556-4029.2012.02280.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1556-4029.2012.02280.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T22:59:02Z","timestamp":1744153142000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1556-4029.2012.02280.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,20]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/j.1556-4029.2012.02280.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1556-4029.2012.02280.x","archive":["Portico"],"relation":{},"ISSN":["0022-1198","1556-4029"],"issn-type":[{"value":"0022-1198","type":"print"},{"value":"1556-4029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,20]]}}}