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The authors report here a randomized, double\u2010blind placebo\u2010controlled trial (N=348; chromium picolinate and biotin combination [CPB]: 226, placebo: 122; T2DM participants with hemoglobin A<jats:sub>1c<\/jats:sub> [HbA<jats:sub>1c<\/jats:sub>] \u22657%) evaluating the effects of CPB on lipid and lipoprotein levels. Participants were randomly assigned (2:1 ratio) to receive either CPB (600 \u03bcg chromium as chromium picolinate and 2 mg biotin) or a matching placebo once daily for 90 days. Statistical analyses were conducted in all eligible participants. Subsequent supplemental analyses were performed in T2DM participants with hypercholesterolemia (HC) and in those using stable doses of statins. In the primary analysis, CPB lowered HbA<jats:sub>1c<\/jats:sub> (<\/jats:italic>P<jats:italic>&lt;.05) and glucose (<\/jats:italic>P<jats:italic>&lt;.02) significantly compared with the placebo group. No significant changes were observed in other lipid levels. In participants with HC and T2DM, significant changes in total cholesterol and low\u2010density lipoprotein cholesterol (LDL\u2010C) levels and atherogenic index were observed in the CPB group (<\/jats:italic>P<jats:italic>&lt;.05). Significant decreases in LDL\u2010C, total cholesterol, HbA<jats:sub>1c<\/jats:sub> , and very low\u2010density cholesterol levels (<\/jats:italic>P<jats:italic>&lt;.05) were observed in the CPB group taking statins. CPB treatment was well tolerated with no adverse effects, dissimilar from those associated with placebo. These data suggest that intervention with CPB improves cardiometabolic risk factors.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1559-4564.2007.06366.x","type":"journal-article","created":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T13:28:18Z","timestamp":1180704498000},"page":"91-97","source":"Crossref","is-referenced-by-count":34,"title":["Combination of Chromium and Biotin Improves Coronary Risk Factors in Hypercholesterolemic Type 2 Diabetes Mellitus: A Placebo\u2010Controlled, Double\u2010Blind Randomized Clinical Trial"],"prefix":"10.1111","volume":"2","author":[{"given":"Cesar","family":"Albarracin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcham","family":"Fuqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Geohas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya","family":"Juturu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manley R.","family":"Finch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Komorowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6]]},"reference":[{"key":"e_1_2_7_2_2","unstructured":"National Cholesterol Education Program; National Heart Lung and Blood Institute; National Institutes of Health; US Department of Health and Human Services.High blood cholesterol: what you need to know. NIH Publication 05\u20103290.http:\/\/www.nhlbi.nih.gov\/health\/public\/heart\/chol\/wyntk. 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