{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:24:10Z","timestamp":1791239050253,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1111\/j.1567-1364.2006.00082.x","type":"journal-article","created":{"date-parts":[[2006,3,24]],"date-time":"2006-03-24T16:15:27Z","timestamp":1143216927000},"page":"599-607","source":"Crossref","is-referenced-by-count":123,"title":["Unique hybrids between the fungal pathogens<i>Cryptococcus neoformans<\/i>and<i>Cryptococcus gattii<\/i>"],"prefix":"10.1093","volume":"6","author":[{"given":"Marjan","family":"Bovers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferry","family":"Hagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiko E.","family":"Kuramae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara R.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lodewijk","family":"Spanjaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00c3\u00a7oise","family":"Dromer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans L.","family":"Hoogveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teun","family":"Boekhout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB1","unstructured":"Bar\u00c3\u00b3 T , Torres-Rodr\u00c3\u00adguez JM , de Hermoso M , Morera Y & Al\u00c3\u00ada C (1998) First identification of autochthonous Cryptococcus neoformans var. gattii isolated from goats with predominantly severe pulmonary disease in Spain. J Clin Microbiol 36: 458\u00e2\u0080\u0093461."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB2","doi-asserted-by":"crossref","unstructured":"Barreto de Oliviera MT , Boekhout T , Theelen B , et al. (2004) Cryptococcus neoformans shows a remarkable genotypic diversity in Brazil. J Clin Microbiol 42: 1356\u00e2\u0080\u00931359.","DOI":"10.1128\/JCM.42.3.1356-1359.2004"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB3","doi-asserted-by":"crossref","unstructured":"Biswas SK , Wang L , Yokoyama K & Nishimura K (2003) Molecular analysis of Cryptococcus neoformans mitochondrial cytochrome b gene sequences. J Clin Microbiol 41: 5572\u00e2\u0080\u00935576.","DOI":"10.1128\/JCM.41.12.5572-5576.2003"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB4","doi-asserted-by":"crossref","unstructured":"Boekhout T , Theelen B , Diaz M , et al. (2001) Hybrid genotypes in the pathogenic yeast Cryptococcus neoformans. Microbiology 147: 891\u00e2\u0080\u0093907.","DOI":"10.1099\/00221287-147-4-891"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB5","unstructured":"Bolano A , Stinchi S , Preziosi R , et al. (2001) Rapid methods to extract DNA and RNA from Cryptococcus neoformans. FEMS Yeast Res 1: 221\u00e2\u0080\u0093224."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB6","unstructured":"Butler MI & Poulter RTM (2005) The PRP8 inteins in Cryptococcus are a source of phylogenetic and epidemiological information. Fungal Genet Biol 42: 452\u00e2\u0080\u0093463."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB7","doi-asserted-by":"crossref","DOI":"10.1128\/9781555818241","volume-title":"Cryptococcus neoformans","author":"Casadevall","year":"1998"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB8","doi-asserted-by":"crossref","unstructured":"Chaturvedi V , Fan J , Stein B , Behr MJ , Samsonoff WA , Wickes BL & Chaturvedi S (2002) Molecular genetic analyses of mating pheromones reveal intervariety mating or hybridization in Cryptococcus neoformans. Infect Immun 70: 5225\u00e2\u0080\u00935235.","DOI":"10.1128\/IAI.70.9.5225-5235.2002"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB9","unstructured":"Colom MF , Fras\u00c3\u00a9s S , Ferrer C , Jover A , Andreu M , Reus S , S\u00c3\u00a1nchez M & Torres-Rodr\u00c3\u00adguez JM (2005) First case of human cryptococcosis due to Cryptococcus neoformans var. gattii in Spain. J Clin Microbiol 43: 3548\u00e2\u0080\u00933550."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB10","volume-title":"Methods in Cell Biology. Flow Cytometry","author":"Darzynkiewicz","year":"1994"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB11","unstructured":"Diaz MR & Fell JW (2005) Use of a suspension array for rapid identificaton of the varieties and genotypes of the Cryptococcus neoformans species complex. J Clin Microbiol 43: 3662\u00e2\u0080\u00933672."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB13","doi-asserted-by":"crossref","unstructured":"Diaz MR , Boekhout T , Theelen B & Fell JW (2000) Molecular sequence analyses of the intergenic spacer (IGS) associated with rDNA of the two varieties of the pathogenic yeast, Cryptococcus neoformans. Syst Appl Microbiol 23: 535\u00e2\u0080\u0093545.","DOI":"10.1016\/S0723-2020(00)80028-4"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB12","unstructured":"Diaz MR , Boekhout T , Kiesling T & Fell JW (2005) Comparative analysis of the intergenic spacer regions and population structure of the species complex of the pathogenic yeast Cryptococcus neoformans. FEMS Yeast Res 5: 1129\u00e2\u0080\u00931140."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB14","doi-asserted-by":"crossref","unstructured":"D'Souza CA , Hagen F , Boekhout T , Cox GM & Heitman J (2004) Investigation of the basis of virulence in serotype A strains of Cryptococcus neoformans from apparently immunocompetent individuals. Curr Genet 46: 92\u00e2\u0080\u0093102.","DOI":"10.1007\/s00294-004-0511-y"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB15","unstructured":"Fulton R , McDade R , Smith P , Kienker L & Kettman J (1997) Advanced multiplexed analysis with the FlowMetrix system. Clin Chem 43: 1749\u00e2\u0080\u00931756."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB16","unstructured":"Halliday CL , Bui T , Krockenberger M , Malik R , Ellis DH & Carter DA (1999) Presence of \u00ce\u00b1 and a mating types in environmental and clinical collections of Cryptococcus neoformans var. gattii strains from Australia. J Clin Microbiol 37: 2920\u00e2\u0080\u00932926."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB17","doi-asserted-by":"crossref","unstructured":"Kellis M , Birren BW & Lander ES (2004) Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae. Nature 428: 617\u00e2\u0080\u0093624.","DOI":"10.1038\/nature02424"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB18","doi-asserted-by":"crossref","unstructured":"Kidd SE , Hagen F , Tscharke RL , et al. (2004) A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada). Proc Natl Acad Sci USA 101: 17258\u00e2\u0080\u009317263.","DOI":"10.1073\/pnas.0402981101"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB19","unstructured":"Kwon-Chung KJ & Bennett JE (1984) Epidemiological differences between the two varieties of Cryptococcus neoformans. Am J Epidemiol 120: 123\u00e2\u0080\u0093130."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB20","doi-asserted-by":"crossref","unstructured":"Kwon-Chung KJ , Polacheck I & Bennett JE (1982a) Improved diagnostic medium for separation of Cryptococcus neoformans var. neoformans (serotypes A and D) and Cryptococcus neoformans var. gattii (serotypes B and C). J Clin Microbiol 15: 535\u00e2\u0080\u0093537.","DOI":"10.1128\/JCM.15.3.535-537.1982"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB21","doi-asserted-by":"crossref","unstructured":"Kwon-Chung KJ , Bennett JE & Rhodes JC (1982b) Taxonomic studies on Filobasidiella species and their anamorphs. Antonie van Leeuwenhoek 48: 25\u00e2\u0080\u009338.","DOI":"10.1007\/BF00399484"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB22","unstructured":"Kwon-Chung KJ , Boekhout T , Fell JW & Diaz M (2002) Proposal to conserve the name Cryptococcus gattii against C. hondurianus and C. bacillisporus (Basidiomycota, Hymenomycetes, Tremellomycetidae). Taxon 51: 804\u00e2\u0080\u0093806."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB23","doi-asserted-by":"crossref","unstructured":"Latouche GN , Huynh M , Sorrell TC & Meyer W (2003) PCR-Restriction Fragment Length Polymorphism analysis of the Phospholipase B (PLB1) gene for subtyping of Cryptococcus neoformans isolates. Appl Environ Microbiol 69: 2080\u00e2\u0080\u00932086.","DOI":"10.1128\/AEM.69.4.2080-2086.2003"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB24","doi-asserted-by":"crossref","unstructured":"Lengeler KB , Cox GM & Heitman J (2001) Serotype AD strains of Cryptococcus neoformans are diploid or aneuploid and are heterozygous at the mating-type locus. Infect Immun 69: 115\u00e2\u0080\u0093122.","DOI":"10.1128\/IAI.69.1.115-122.2001"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB25","doi-asserted-by":"crossref","unstructured":"Liao D (1999) Concerted evolution: molecular mechanism and biological implications. Am J Hum Genet 64: 24\u00e2\u0080\u009330.","DOI":"10.1086\/302221"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB26","doi-asserted-by":"crossref","unstructured":"Matheny PB (2005) Improving phylogenetic inference of mushrooms with RPB1 and RPB2 nucleotide sequences (Inocybe; Agaricales). Mol Phylogenet Evol 35: 1\u00e2\u0080\u009320.","DOI":"10.1016\/j.ympev.2004.11.014"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB27","unstructured":"Meyer W , Marszewska K , Amirmostofian M , et al. (1999) Molecular typing of global isolates of Cryptococcus neoformans var. neoformans by polymerase chain reaction fingerprinting and randomly amplified polymorphic DNA \u00e2\u0080\u0093 a pilot study to standardize techniques on which to base a detailed epidemiological survey. Electrophoresis 20: 1790\u00e2\u0080\u00931799."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB29","first-page":"88","author":"Meyer","year":"2002"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB28","unstructured":"Meyer W , Casta\u00c3\u00b1eda A , Jackson S , Huynh M & Casta\u00c3\u00b1eda E and the IberoAmerican Cryptococcal study group (2003) Molecular typing of IberoAmerican Cryptococcus neoformans isolates. Emerging Infect Dis 9: 189\u00e2\u0080\u0093195."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB30","unstructured":"Montagna MT , Viviani MA , Pulito A , Aralla C , Tortorano AM , Fiore L & Barbuti S (1997) Cryptococcus neoformans var. gattii in Italy. Note II. Environmental investigation related to an autochtonous clinical case in Apulia. J Mycol M\u00c3\u00a9d 7: 93\u00e2\u0080\u009396."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB31","unstructured":"Nguyen HV , L\u00c3\u00a9pingle A & Gaillardin C (2000) Molecular typing demonstrates homogeneity of Saccharomyces uvarum and reveals the existence of hybrids between S. uvarum and S. cerevisiae, including the S. bayanus type strain CBS 380. Syst Appl Microbiol 23: 71\u00e2\u0080\u009385."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB32","doi-asserted-by":"crossref","unstructured":"Ruma P , Chen SC , Sorrell TC & Brownlee AG (1996) Characterization of Cryptococcus neoformans by random DNA amplification. Lett Appl Microbiol 23: 312\u00e2\u0080\u0093316.","DOI":"10.1111\/j.1472-765X.1996.tb00197.x"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB33","unstructured":"Speed B & Dunt D (1995) Clinical and host differences between infections with the two varieties of Cryptococcus neoformans. Clin Infect Dis 21: 28\u00e2\u0080\u009334."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB34","doi-asserted-by":"crossref","unstructured":"Sorrell TC (2001) Cryptococcus neoformans variety gattii. Med Mycol 39: 155\u00e2\u0080\u0093168.","DOI":"10.1080\/714031012"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB35","unstructured":"Sorrell TC , Chen SCA , Ruma P , Meyer W , Pfeiffer TJ , Ellis DH & Brownlee AG (1996) Concordance of clinical and environmental isolates of Cryptococcus neoformans var. gattii by random amplification of polymorphic DNA analysis and PCR fingerprinting. J Clin Microbiol 34: 1253\u00e2\u0080\u00931260."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB36","unstructured":"Sugita T , Ikeda R & Shinoda T (2001) Diversity among strains of Cryptococcus neoformans var. gattii as revealed by a sequence analysis of multiple genes and a chemotype analysis of capsular polysaccharide. Microbiol Immunol 45: 757\u00e2\u0080\u0093768."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB37","author":"Varma","year":"2002"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB38","doi-asserted-by":"crossref","unstructured":"Vaughan-Martini A & Kurtzman CP (1985) Deoxyribonucleic acid relatedness among species of Saccharomyces sensu stricto. Int J Syst Bacteriol 35: 508\u00e2\u0080\u0093511.","DOI":"10.1099\/00207713-35-4-508"},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB39","unstructured":"Velegraki A , Kiosses VG , Pitsouni H , Toukas D , Daniilidis VD & Legakis NJ (2001) First report of Cryptococcus neoformans var. gattii serotype B from Greece. Med Mycol 39: 419\u00e2\u0080\u0093422."},{"key":"10.1111\/j.1567-1364.2006.00082.x-BIB40","doi-asserted-by":"crossref","unstructured":"Xu J , Vilgalys R & Mitchell TG (2000) Multiple gene genealogies reveal recent dispersion and hybridization in the human pathogenic fungus Cryptococcus neoformans. Mol Ecol 9: 1471\u00e2\u0080\u00931481.","DOI":"10.1046\/j.1365-294x.2000.01021.x"}],"container-title":["FEMS Yeast Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femsyr\/article-pdf\/6\/4\/599\/17939433\/6-4-599.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T13:01:06Z","timestamp":1706965266000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femsyr\/article-lookup\/doi\/10.1111\/j.1567-1364.2006.00082.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,6]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1567-1364.2006.00082.x","relation":{},"ISSN":["1567-1356","1567-1364"],"issn-type":[{"value":"1567-1356","type":"print"},{"value":"1567-1364","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}