{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:56:18Z","timestamp":1786546578816,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,3]]},"abstract":"\n ABSTRACT<\/jats:bold>\n <\/jats:title>\n \n OBJECTIVE:<\/jats:title>\n \n Recently we reported a close association between lymphonodular hyperplasia (LNH) of the bulb of the duodenum and increased densities of intraepithelial \u03b3\u03b4\n +<\/jats:sup>\n T-cells in subjects with untreated food allergies. In this study we sought to determine whether children with LNH of the terminal ileum (TI) show a similar correlation.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n The mucosal specimens taken by colonoscopy from the TIs of 22 children with LNH of the TI without colitis, 13 with right-sided colitis or pancolitis, nine with left-sided colitis, eight with Crohn's disease, and three endoscopically healthy subjects were studied for T-cell subsets with monoclonal antibodies using a three-layer peroxidase staining method.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n LNH of the TI was found in 32 of the 55 subjects (58%). In 22 it was the only endoscopic finding, but in nine of 13 subjects (69%) it was related to right-sided colitis or pancolitis. In patients with left-sided colitis or Crohn's disease it was diagnosed only rarely. In the whole study population, LNH of the TI showed a significant association with the increment in the density of \u03b3\u03b4\n +<\/jats:sup>\n T-cells. The subjects with LNH of the TI and colitis starting from the cecum showed the highest values, discriminating them statistically from any other study group. Accordingly their \u03b3\u03b4\n +<\/jats:sup>\n \/CD3\n +<\/jats:sup>\n ratio was high. Even in the subjects with LNH of the TI without colitis, the increment in \u03b3\u03b4\n +<\/jats:sup>\n T-cells was significant as compared with the subjects with left-sided colitis. Upregulations of D-related expression on the mucosa of the TI were similar regardless of the presence of LNH or colitis or an increment in \u03b3\u03b4\n +<\/jats:sup>\n T-cells.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n \n Our preliminary observations showed increased densities of intraepithelial \u03b3\u03b4\n +<\/jats:sup>\n T-cells and elevated \u03b3\u03b4\n +<\/jats:sup>\n \/CD3+ ratios in subjects with LNH on the mucosa of the TI, especially if related to colitis starting at the cecum, but not in subjects with typical left-sided colitis or granulomatous Crohn's disease. The study also provides further evidence suggesting the significance of food-borne antigens in the pathogenetic mechanism of right-sided colitis or pancolitis. The finding also indicates the significance of classifying colitis into \u03b3\u03b4-positive and -negative diseases, and has implications for the treatment of these entities.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1572-0241.2002.05547.x","type":"journal-article","created":{"date-parts":[[2004,3,29]],"date-time":"2004-03-29T04:05:14Z","timestamp":1080533114000},"page":"667-672","source":"Crossref","is-referenced-by-count":9,"title":["Lymphonodular Hyperplasia of The Terminal Ileum Associated With Colitis Shows An Increased \u03b3\u03b4+ T-Cell Density in Children"],"prefix":"10.14309","volume":"97","author":[{"given":"Jorma","family":"Kokkonen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarja","family":"Ruuska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomo J","family":"Karttunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"M\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"b1_912","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91262-7"},{"key":"b2_913","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750056592"},{"key":"b3_914","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1203\/00006450-199012000-00005","volume":"28","author":"Savilahti E.","year":"1990","journal-title":"Pediatr Res"},{"key":"b4_915","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.4049\/jimmunol.156.6.2331","volume":"156","author":"Soderstrom K.","year":"1996","journal-title":"J Immunol"},{"key":"b5_916","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/0016-5085(91)90524-O","volume":"101","author":"Fukushima K.","year":"1991","journal-title":"Gastroenterology"},{"key":"b6_917","first-page":"1256","volume-title":"Pediatric gastroenterology","author":"Bines JE","year":"1991"},{"key":"b7_918","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199907000-00015"},{"key":"b8_919","doi-asserted-by":"publisher","DOI":"10.1055\/s-1999-51"},{"key":"b9_920","first-page":"1006","volume":"32","author":"Magista AM","year":"2000","journal-title":"Endoscopy"},{"key":"b10_921","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0016-5085(98)70381-6","volume":"115","author":"Fiocchi C.","year":"1998","journal-title":"Gastroenterology"},{"key":"b11_922","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/00005176-199408000-00007","volume":"19","author":"Ruuska T.","year":"1994","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"b12_923","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1136\/gut.32.11.1412","volume":"32","author":"Maki M.","year":"1991","journal-title":"Gut"},{"issue":"1","key":"b13_924","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1365-2222.1995.tb00997.x","volume":"25","author":"Donald T.","year":"1995","journal-title":"Clin Exp Allergy"},{"key":"b14_925","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/eji.1830260432","volume":"26","author":"Duchmann R.","year":"1996","journal-title":"Eur J Immunol"},{"key":"b15_926","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00005176-199408000-00006","volume":"19","author":"Ruuska T.","year":"1994","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"b16_927","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01527.x"},{"key":"b17_928","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/08916939908998533","volume":"29","author":"Iltanen S.","year":"1999","journal-title":"Autoimmunity"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00000434-200203000-00031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:59:27Z","timestamp":1786543167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-200203000-00031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1572-0241.2002.05547.x","relation":{},"ISSN":["0002-9270"],"issn-type":[{"value":"0002-9270","type":"print"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}