{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:31:23Z","timestamp":1786545083199,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,3]]},"abstract":"\n ABSTRACT<\/jats:bold>\n <\/jats:title>\n \n OBJECTIVES:<\/jats:title>\n Inflammatory bowel disease (IBD) is usually diagnosed as a result of symptoms but occasionally is found during investigation for other conditions. An earlier report from Nottingham had found a high prevalence of previously undetected \u201casymptomatic\u201d IBD detected as a result of colorectal cancer screening, and the aim of this study was to reassess the prevalence, symptoms, and outcome in these patients.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n We investigated subjects found to be fecal occult blood (FOB) positive in a randomized trial of FOB screening for colorectal cancer. All FOB-positive subjects were investigated by colonoscopy or flexible sigmoidoscopy and barium enema. Subjects with IBD were referred back to their general practitioner for any further investigation and treatment.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Seventy-five thousand two hundred fifty-three subjects (aged 45\u201374) were sent FOB tests and 44,838 (60%) completed a series of tests on one or more occasions. Of 133,000 test series, 1.5% were positive. During investigation 53 cases of previously undetected IBD (52 of ulcerative colitis) were found; 52% (27\/52) had proctosigmoiditis only, whereas 25% (13\/52) had pancolitis. Only 17% (9\/52) were completely asymptomatic, with a half or more reporting some rectal bleeding (54%) or diarrhea (50%). The overall prevalence of undetected ulcerative colitis was 69\/10\n 5<\/jats:sup>\n (95% CI = 50\u201388\/10\n 5<\/jats:sup>\n ) in people offered screening and 116\/10\n 5<\/jats:sup>\n (95% CI = 85\u2013147\/10\n 5<\/jats:sup>\n ) in people accepting screening and was higher in men. Of 32 subjects followed up 2\u201312 yr after diagnosis, 91% (29) continued to have few or no symptoms, with only 12 currently receiving any treatment for their colitis.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n In comparison with detected disease, undetected ulcerative colitis is relatively common but does usually cause some symptoms. It generally appears to follow a benign course, but a significant proportion have extensive colitis and may therefore be at an increased risk of colorectal cancer.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1572-0241.2002.05586.x","type":"journal-article","created":{"date-parts":[[2004,3,29]],"date-time":"2004-03-29T04:05:14Z","timestamp":1080533114000},"page":"690-694","source":"Crossref","is-referenced-by-count":29,"title":["High Prevalence of Undetected Ulcerative Colitis: Data From The Nottingham Fecal Occult Blood Screening Trial"],"prefix":"10.14309","volume":"97","author":[{"given":"G F","family":"Howarth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M H E","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J D","family":"Hardcastle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R F A","family":"Logan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"b1_1027","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)03386-7"},{"key":"b2_1028","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/gut.30.4.481","volume":"30","author":"Mayberry JF","year":"1989","journal-title":"Gut"},{"key":"b3_1029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jcp.50.1.1","volume":"50","author":"Jenkins D.","year":"1997","journal-title":"J Clin Pathol"},{"key":"b4_1030","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1136\/gut.39.5.690","volume":"39","author":"Shivananda S.","year":"1996","journal-title":"Gut"},{"key":"b5_1031","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1136\/gut.35.10.1433","volume":"35","author":"Gower-Rousseau C.","year":"1994","journal-title":"Gut"},{"key":"b6_1032","doi-asserted-by":"crossref","first-page":"945","DOI":"10.3109\/00365529209000168","volume":"27","author":"Tysk C.","year":"1992","journal-title":"Scand J Gastroenterol"},{"key":"b7_1033","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00886.x"},{"key":"b8_1034","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1136\/bmj.316.7137.1058","volume":"316","author":"Montgomery SM","year":"1998","journal-title":"BMJ"},{"key":"b9_1035","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1093\/oxfordjournals.aje.a009735","volume":"149","author":"Bernstein CN","year":"1999","journal-title":"Am J Epidemiol"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00000434-200203000-00034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:35:59Z","timestamp":1786541759000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-200203000-00034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1572-0241.2002.05586.x","relation":{},"ISSN":["0002-9270"],"issn-type":[{"value":"0002-9270","type":"print"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}