{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:00:36Z","timestamp":1789725636972,"version":"4.0.1"},"reference-count":97,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Gastroenterology"],"published-print":{"date-parts":[[2003,4]]},"DOI":"10.1111\/j.1572-0241.2003.07306.x","type":"journal-article","created":{"date-parts":[[2004,3,23]],"date-time":"2004-03-23T09:10:07Z","timestamp":1080033007000},"page":"750-758","source":"Crossref","is-referenced-by-count":66,"title":["Pharmacologic therapy for the irritable bowel syndrome"],"prefix":"10.14309","volume":"98","author":[{"given":"Nicholas J.","family":"Talley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"b1_169","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37095"},{"key":"b2_170","unstructured":"2. D.A. Drossman, E. Corazziari, and N.J. Talley, Rome II. The functional gastrointestinal disorders . McLean, VA: Degnon2000 ."},{"key":"b3_171","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(98)00321-9"},{"key":"b4_172","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90341-4"},{"key":"b5_173","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1136\/gut.44.3.400","volume":"44","author":"Gwee K.A.","year":"1999","journal-title":"Gut"},{"key":"b6_174","first-page":"1675","volume":"91","author":"Talley N.J.","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"b7_175","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.6.804"},{"key":"b8_176","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0016-5085(97)70219-1","volume":"112","author":"Munakata J.","year":"1997","journal-title":"Gastroenterology"},{"key":"b9_177","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(00)70170-3","volume":"118","author":"Mertz H.","year":"2000","journal-title":"Gastroenterology"},{"key":"b10_178","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03177.x"},{"key":"b11_179","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.2.272"},{"key":"b12_180","doi-asserted-by":"crossref","first-page":"136","DOI":"10.7326\/0003-4819-133-2-200007180-00013","volume":"133","author":"Jailwala J.","year":"2000","journal-title":"Ann Intern Med"},{"key":"b13_181","doi-asserted-by":"crossref","first-page":"A640","DOI":"10.1016\/S0016-5085(08)83180-0","volume":"120","author":"Nothcutt A.R.","year":"2001","journal-title":"Gastroenterology"},{"key":"b14_182","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00937.x"},{"key":"b15_183","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00004836-198106000-00009","volume":"3","author":"Page J.G.","year":"1981","journal-title":"J Clin Gastroenterol"},{"key":"b16_184","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00299-5"},{"key":"b17_185","doi-asserted-by":"crossref","first-page":"A641","DOI":"10.1016\/S0016-5085(08)83187-3","volume":"120","author":"Broekaert D.","year":"2001","journal-title":"Gastroenterology"},{"key":"b18_186","first-page":"A-551","volume-title":"Gastroenterology","volume":"122","author":"Kuiken SD","year":"2002"},{"key":"b19_187","first-page":"303","volume-title":"Gastroenterology","volume":"124","author":"Creed F","year":"2003"},{"key":"b20_188","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJM197301042880103","volume":"288","author":"Greenbaum D.S.","year":"1973","journal-title":"N Engl J Med"},{"key":"b21_189","first-page":"67","volume":"85756","author":"McIntyre A.S.","year":"1998","journal-title":"Lancet"},{"key":"b22_190","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018888631286"},{"key":"b23_191","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/BF02093778","volume":"39","author":"Mathias J.R.","year":"1994","journal-title":"Dig Dis Sci"},{"key":"b24_192","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/00007611-200105000-00006","volume":"94","author":"Cleveland M.V.","year":"2001","journal-title":"South Med J"},{"key":"b25_193","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/BF02234645","volume":"44","author":"Xing J.H.","year":"2001","journal-title":"Dis Colon Rectum"},{"key":"b26_194","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)07103-3"},{"key":"b27_195","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2036.1992.tb00050.x","volume":"6","author":"Talley N.J.","year":"1992","journal-title":"Aliment Pharmacol Ther"},{"key":"b28_196","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.133311000.x"},{"key":"b29_197","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850171873"},{"key":"b30_198","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850166833"},{"key":"b31_199","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00925.x"},{"key":"b32_200","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0016-5085(00)70251-4","volume":"118","author":"Prather C.M.","year":"2000","journal-title":"Gastroenterology"},{"key":"b33_201","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01103.x"},{"key":"b34_202","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01094.x"},{"key":"b35_203","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01372.x"},{"key":"b36_204","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018883731556"},{"key":"b37_205","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200108000-00012"},{"key":"b38_206","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.00237.x"},{"key":"b39_207","first-page":"1653","volume":"4","author":"Talley N.J.","year":"2001","journal-title":"Aliment Pharmacol Ther"},{"key":"b40_208","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF01296258","volume":"29","author":"Cann P.A.","year":"1984","journal-title":"Dig Dis Sci"},{"key":"b41_209","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1007\/BF02087698","volume":"39","author":"Hallgren T.","year":"1994","journal-title":"Dig Dis Sci"},{"key":"b42_210","first-page":"448","volume":"34","author":"Smith M.J.","year":"2000","journal-title":"J R Coll Physicians Lond"},{"key":"b43_211","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF01536922","volume":"35","author":"Talley N.J.","year":"1990","journal-title":"Dig Dis Sci"},{"key":"b44_212","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/BF01537102","volume":"34","author":"Talley N.J.","year":"1989","journal-title":"Dig Dis Sci"},{"key":"b45_213","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1365-2036.1993.tb00131.x","volume":"7","author":"Hammer J.","year":"1993","journal-title":"Aliment Pharmacol Ther"},{"key":"b46_214","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/BF02064986","volume":"40","author":"Zighelboim J.","year":"1995","journal-title":"Dig Dis Sci"},{"key":"b47_215","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/S0025-6196(12)60797-6","volume":"67","author":"Steadman C.J.","year":"1992","journal-title":"Mayo Clinic Proc"},{"key":"b48_216","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.d01-1389.x"},{"key":"b49_217","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.4.474"},{"key":"b50_218","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00375.x"},{"key":"b51_219","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00762.x"},{"key":"b52_220","doi-asserted-by":"crossref","first-page":"G974","DOI":"10.1152\/ajpgi.2001.281.4.G974","volume":"281","author":"Bush T.G.","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"b53_221","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02033-X"},{"key":"b54_222","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.14.1733"},{"key":"b55_223","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.04128.x"},{"key":"b56_224","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00678.x"},{"key":"b57_225","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(01)03784-4"},{"key":"b58_226","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1517\/14740338.1.1.1","volume":"1","author":"Hyman P.E.","year":"2002","journal-title":"Exp Opin Drug Safety"},{"key":"b59_227","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1053\/gast.2001.21177","volume":"120","author":"Fridel D.","year":"2001","journal-title":"Gastroenterology"},{"key":"b60_228","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91564-9"},{"key":"b61_229","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/BF02093780","volume":"39","author":"Bradette M.","year":"1994","journal-title":"Dig Dis Sci"},{"key":"b62_230","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91055-3"},{"key":"b63_231","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s11938-001-0059-6","volume":"4","author":"Fink R.N.","year":"2001","journal-title":"Curr Treatment Options Gastroenterol"},{"key":"b64_232","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02015.x"},{"key":"b65_233","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200110000-00004"},{"key":"b66_234","first-page":"A59","volume":"122","author":"Quigley E.","year":"2002","journal-title":"Gastroenterology"},{"key":"b67_235","first-page":"441","volume":"39","author":"Ganiats T.G.","year":"1994","journal-title":"J Fam Pract"},{"key":"b68_236","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(00)02161-4"},{"key":"b69_237","doi-asserted-by":"crossref","first-page":"A60","DOI":"10.1053\/gast.2002.30306","volume":"122","author":"Pimental M.","year":"2002","journal-title":"Gastroenterology"},{"key":"b70_238","first-page":"A465","volume":"122","author":"Moayyedi P.","year":"2002","journal-title":"Gastroenterology"},{"key":"b71_239","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.1.14"},{"key":"b72_240","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1136\/gut.43.1.100","volume":"43","author":"Suarez F.L.","year":"1998","journal-title":"Gut"},{"key":"b73_241","first-page":"1585","volume":"18","author":"Bensoussan A","year":"1998","journal-title":"A randomized controlled trial"},{"key":"b74_242","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.00189.x"},{"key":"b75_243","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1996.04222.x"},{"key":"b76_244","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1016\/S0016-5085(99)70226-X","volume":"116","author":"Delvaux M.","year":"1999","journal-title":"Gastroenterology"},{"key":"b77_245","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1007\/BF02209014","volume":"40","author":"Dapoigny M.","year":"1995","journal-title":"Dig Dis Sci"},{"key":"b78_246","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01301-2"},{"key":"b79_247","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00468-4"},{"key":"b80_248","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1053\/gast.2001.21166","volume":"120","author":"Bouras E.P.","year":"2001","journal-title":"Gastroenterology"},{"key":"b81_249","doi-asserted-by":"crossref","first-page":"A175","DOI":"10.1016\/S0016-5085(00)82777-8","volume":"118","author":"Johanson J.F.","year":"2000","journal-title":"Gastroenterology"},{"key":"b82_250","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1155\/1999\/183697","volume":"13","author":"Scarpignato C.","year":"1999","journal-title":"Can J Gastroenterol"},{"issue":"1","key":"b83_251","first-page":"A44","volume":"48","author":"Coleman N.","year":"2001","journal-title":"Gut"},{"key":"b84_252","first-page":"A981","volume":"116","author":"D'Amato M.","year":"1999","journal-title":"Gastroenterology"},{"key":"b85_253","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(01)03783-2"},{"key":"b86_254","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01320.x"},{"key":"b87_255","doi-asserted-by":"crossref","first-page":"A1139","DOI":"10.1016\/S0016-5085(08)81078-5","volume":"120","author":"Caras S.","year":"2001","journal-title":"Gastroenterology"},{"key":"b88_256","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.5.667"},{"key":"b89_257","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00757.x"},{"key":"b90_258","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1365-2036.1988.tb00728.x","volume":"2","author":"Prior A.","year":"1988","journal-title":"Aliment Pharmacol Ther"},{"key":"b91_259","first-page":"169","volume":"30","author":"Awad R.A.","year":"2000","journal-title":"Act Gastroenterol Latinoam"},{"key":"b92_260","doi-asserted-by":"crossref","first-page":"604","DOI":"10.5694\/j.1326-5377.1989.tb136704.x","volume":"150","author":"Borody T.","year":"1989","journal-title":"Med J Aust"},{"key":"b93_261","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(98)00224-X"},{"key":"b94_262","first-page":"765","volume":"32","author":"Liu J.H.","year":"1997","journal-title":"Gastroenterology"},{"key":"b95_263","doi-asserted-by":"publisher","DOI":"10.1159\/000048847"},{"key":"b96_264","first-page":"277","volume":"91","author":"Talley N.J.","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"b97_265","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09712-X"}],"container-title":["The American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1111\/j.1572-0241.2003.07306.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T23:04:24Z","timestamp":1638054264000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nature.com\/doifinder\/10.1111\/j.1572-0241.2003.07306.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":97,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["10.1111\/j.1572-0241.2003.07306.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1572-0241.2003.07306.x","relation":{},"ISSN":["0002-9270","1572-0241"],"issn-type":[{"value":"0002-9270","type":"print"},{"value":"1572-0241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}