{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:32:46Z","timestamp":1790469166605,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1111\/j.1574-6968.2006.00407.x","type":"journal-article","created":{"date-parts":[[2006,8,17]],"date-time":"2006-08-17T14:59:46Z","timestamp":1155826786000},"page":"109-118","source":"Crossref","is-referenced-by-count":19,"title":["Meningococcal adhesion suppresses proapoptotic gene expression and promotes expression of genes supporting early embryonic and cytoprotective signaling of human endothelial cells"],"prefix":"10.1093","volume":"263","author":[{"given":"Irena","family":"Linhartova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Basler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Pelicic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radim","family":"Osicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Lory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Nassif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sebo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB1","unstructured":"Allaker RP & Kapas S (2003) Adrenomedullin and mucosal defence: interaction between host and microorganism. Regul Pept 112: 147\u00e2\u0080\u0093152."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB2","doi-asserted-by":"crossref","unstructured":"Badea TC , Niculescu FI , Soane L , Shin ML & Rus H (1998) Molecular cloning and characterization of RGC-32, a novel gene induced by complement activation in oligodendrocytes. J Biol Chem 273: 26977\u00e2\u0080\u009326981.","DOI":"10.1074\/jbc.273.41.26977"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB3","unstructured":"Barrett T , Suzek TO , Troup DB , Wilhite SE , Ngau WC , Ledoux P , Rudnev D , Lash AE , Fujibuchi W & Edgar R (2005) NCBI GEO: mining millions of expression profiles \u00e2\u0080\u0093 database and tools. Nucleic Acids Res 33: 562\u00e2\u0080\u0093566."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB4","doi-asserted-by":"crossref","unstructured":"Binnicker MJ , Williams RD & Apicella MA (2003) Infection of human urethral epithelium with Neisseria gonorrhoeae elicits an upregulation of host anti-apoptotic factors and protects cells from staurosporine-induced apoptosis. Cell Microbiol 5: 549\u00e2\u0080\u0093560.","DOI":"10.1046\/j.1462-5822.2003.00300.x"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB5","unstructured":"Binnicker MJ , Williams RD & Apicella MA (2004) Gonococcal porin IB activates NF-kappaB in human urethral epithelium and increases the expression of host antiapoptotic factors. Infect Immun 72: 6408\u00e2\u0080\u00936417."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB6","doi-asserted-by":"crossref","unstructured":"Carbonnelle E , Helaine S , Prouvensier L , Nassif X & Pelicic V (2005) Type IV pilus biogenesis in Neisseria meningitidis: PilW is involved in a step occurring after pilus assembly, essential for fibre stability and function. Mol Microbiol 55: 54\u00e2\u0080\u009364.","DOI":"10.1111\/j.1365-2958.2004.04364.x"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB7","doi-asserted-by":"crossref","unstructured":"Christodoulides M , Makepeace BL , Partridge KA , Kaur D , Fowler MI , Weller RO & Heckels JE (2002) Interaction of Neisseria meningitidis with human meningeal cells induces the secretion of a distinct group of chemotactic, proinflammatory, and growth-factor cytokines. Infect Immun 70: 4035\u00e2\u0080\u00934044.","DOI":"10.1128\/IAI.70.8.4035-4044.2002"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB8","doi-asserted-by":"crossref","unstructured":"Dixon GL , Heyderman RS , Kotovicz K , Jack DL , Andersen SR , Vogel U , Frosch M & Klein N (1999) Endothelial adhesion molecule expression and its inhibition by recombinant bactericidal\/permeability-increasing protein are influenced by the capsulation and lipooligosaccharide structure of Neisseria meningitidis. Infect Immun 67: 5626\u00e2\u0080\u00935633.","DOI":"10.1128\/IAI.67.11.5626-5633.1999"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB9","unstructured":"Finlay BB & Cossart P (1997) Exploitation of mammalian host cell functions by bacterial pathogens. Science 276: 718\u00e2\u0080\u0093725."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB10","doi-asserted-by":"crossref","unstructured":"Fischer SF , Schwarz C , Vier J & Hacker G (2001) Characterization of antiapoptotic activities of Chlamydia pneumoniae in human cells. Infect Immun 69: 7121\u00e2\u0080\u00937129.","DOI":"10.1128\/IAI.69.11.7121-7129.2001"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB11","doi-asserted-by":"crossref","unstructured":"Forman S , Linhartova I , Osicka R , Nassif X , Sebo P & Pelicic V (2003) Neisseria meningitidis RTX proteins are not required for virulence in infant rats. Infect Immun 71: 2253\u00e2\u0080\u00932257.","DOI":"10.1128\/IAI.71.4.2253-2257.2003"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB12","doi-asserted-by":"crossref","unstructured":"Gregory CA , Singh H , Perry AS & Prockop DJ (2003) The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow. J Biol Chem 278: 28067\u00e2\u0080\u009328078.","DOI":"10.1074\/jbc.M300373200"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB13","unstructured":"Hernandez MC , Andres-Barquin PJ , Holt I & Israel MA (1998) Cloning of human ENC-1 and evaluation of its expression and regulation in nervous system tumors. Exp Cell Res 242: 470\u00e2\u0080\u0093477."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB14","unstructured":"Heyninck K , Kreike MM & Beyaert R (2003) Structure\u00e2\u0080\u0093function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1. FEBS Lett 536: 135\u00e2\u0080\u0093140."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB15","unstructured":"Howie HL , Glogauer M & So M (2005) The N. gonorrhoeae type IV pilus stimulates mechanosensitive pathways and cytoprotection through a pilT-dependent mechanism. PLoS Biol 3: e100."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB16","doi-asserted-by":"crossref","unstructured":"Irizarry RA , Hobbs B , Collin F , Beazer-Barclay YD , Antonellis KJ , Scherf U & Speed TP (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4: 249\u00e2\u0080\u0093264.","DOI":"10.1093\/biostatistics\/4.2.249"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB17","unstructured":"Kellogg DS Jr , Peacock WL Jr , Deacon WE , Brown L & Pirkle DI (1963) Neisseria gonorrhoeae. I. virulence genetically linked to clonal variation. J Bacteriol 85: 1274\u00e2\u0080\u00931279."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB18","doi-asserted-by":"crossref","unstructured":"Lally ET , Hill RB , Kieba IR & Korostoff J (1999) The interaction between RTX toxins and target cells. Trends Microbiol 7: 356\u00e2\u0080\u0093361.","DOI":"10.1016\/S0966-842X(99)01530-9"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB19","unstructured":"Lee EG , Boone DL , Chai S , Libby SL , Chien M , Lodolce JP & Ma A (2000) Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 289: 2350\u00e2\u0080\u00932354."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB20","unstructured":"Li X , Massa PE , Hanidu A , Peet GW , Aro P , Savitt A , Mische S , Li J & Marcu KB (2002) IKKalpha, IKKbeta, and NEMO\/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program. J Biol Chem 277: 45129\u00e2\u0080\u009345140."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB21","doi-asserted-by":"crossref","unstructured":"Lindner V , Booth C , Prudovsky I , Small D , Maciag T & Liaw L (2001) Members of the Jagged\/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell\u00e2\u0080\u0093cell interaction. Am J Pathol 159: 875\u00e2\u0080\u0093883.","DOI":"10.1016\/S0002-9440(10)61763-4"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB22","doi-asserted-by":"crossref","unstructured":"Mao B , Wu W , Li Y , Hoppe D , Stannek P , Glinka A & Niehrs C (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411: 321\u00e2\u0080\u0093325.","DOI":"10.1038\/35077108"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB23","doi-asserted-by":"crossref","unstructured":"McCormick SM , Eskin SG , McIntire LV , Teng CL , Lu CM , Russell CG & Chittur KK (2001) DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells. Proc Natl Acad Sci USA 98: 8955\u00e2\u0080\u00938960.","DOI":"10.1073\/pnas.171259298"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB24","doi-asserted-by":"crossref","unstructured":"McGuinness BT , Clarke IN , Lambden PR , Barlow AK , Poolman JT , Jones DM & Heckels JE (1991) Point mutation in meningococcal por A gene associated with increased endemic disease. Lancet 337: 514\u00e2\u0080\u0093517.","DOI":"10.1016\/0140-6736(91)91297-8"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB25","doi-asserted-by":"crossref","unstructured":"Nagaya N , Mori H , Murakami S , Kangawa K & Kitamura S (2005) Adrenomedullin: angiogenesis and gene therapy. Am J Physiol Regul Integr Comp Physiol 288: 1432\u00e2\u0080\u00931437.","DOI":"10.1152\/ajpregu.00662.2004"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB26","doi-asserted-by":"crossref","unstructured":"Nakagawa I , Nakata M , Kawabata S & Hamada S (2004) Transcriptome analysis and gene expression profiles of early apoptosis-related genes in Streptococcus pyogenes-infected epithelial cells. Cell Microbiol 6: 939\u00e2\u0080\u0093952.","DOI":"10.1111\/j.1462-5822.2004.00412.x"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB27","unstructured":"Nakao A , Afrakhte M , Moren A et al. (1997) Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature 389: 631\u00e2\u0080\u0093635."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB28","unstructured":"Nakhjiri SF , Park Y , Yilmaz O , Chung WO , Watanabe K , El-Sabaeny A , Park K & Lamont RJ (2001) Inhibition of epithelial cell apoptosis by Porphyromonas gingivalis. FEMS Microbiol Lett 200: 145\u00e2\u0080\u0093149."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB29","doi-asserted-by":"crossref","unstructured":"Nassif X , Beretti JL , Lowy J , Stenberg P , O'Gaora P , Pfeifer J , Normark S & So M (1994) Roles of pilin and PilC in adhesion of Neisseria meningitidis to human epithelial and endothelial cells. Proc Natl Acad Sci USA 91: 3769\u00e2\u0080\u00933773.","DOI":"10.1073\/pnas.91.9.3769"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB30","unstructured":"Nunn DN & Lory S (1991) Product of the Pseudomonas aeruginosa gene pilD is a prepilin leader peptidase. Proc Natl Acad Sci USA 88: 3281\u00e2\u0080\u00933285."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB31","unstructured":"Osicka R , Kalmusova J , Krizova P & Sebo P (2001) Neisseria meningitidis RTX protein FrpC induces high levels of serum antibodies during invasive disease: polymorphism of frpC alleles and purification of recombinant FrpC. Infect Immun 69: 5509\u00e2\u0080\u00935519."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB32","doi-asserted-by":"crossref","unstructured":"Pelicic V , Morelle S , Lampe D & Nassif X (2000) Mutagenesis of Neisseria meningitidis by in vitro transposition of Himar1 mariner. J Bacteriol 182: 5391\u00e2\u0080\u00935398.","DOI":"10.1128\/JB.182.19.5391-5398.2000"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB33","doi-asserted-by":"crossref","unstructured":"Pujol C , Eugene E , Marceau M & Nassif X (1999) The meningococcal PilT protein is required for induction of intimate attachment to epithelial cells following pilus-mediated adhesion. Proc Natl Acad Sci USA 96: 4017\u00e2\u0080\u00934022.","DOI":"10.1073\/pnas.96.7.4017"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB34","doi-asserted-by":"crossref","unstructured":"Roberts AB (2002) The ever-increasing complexity of TGF-beta signaling. Cytokine Growth Factor Rev 13: 3\u00e2\u0080\u00935.","DOI":"10.1016\/S1359-6101(01)00027-2"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB35","doi-asserted-by":"crossref","unstructured":"Robinson K , Taraktsoglou M , Rowe KS , Wooldridge KG & Ala'Aldeen DA (2004) Secreted proteins from Neisseria meningitidis mediate differential human gene expression and immune activation. Cell Microbiol 6: 927\u00e2\u0080\u0093938.","DOI":"10.1111\/j.1462-5822.2004.00410.x"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB36","doi-asserted-by":"crossref","unstructured":"Rudel T , Facius D , Barten R , Scheuerpflug I , Nonnenmacher E & Meyer TF (1995) Role of pili and the phase-variable PilC protein in natural competence for transformation of Neisseria gonorrhoeae. Proc Natl Acad Sci USA 92: 7986\u00e2\u0080\u00937990.","DOI":"10.1073\/pnas.92.17.7986"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB37","doi-asserted-by":"crossref","unstructured":"Sancho D , Gomez M & Sanchez-Madrid F (2005) CD69 is an immunoregulatory molecule induced following activation. Trends Immunol 26: 136\u00e2\u0080\u0093140.","DOI":"10.1016\/j.it.2004.12.006"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB38","unstructured":"Seibold S , Rudroff C , Weber M , Galle J , Wanner C & Marx M (2003) Identification of a new tumor suppressor gene located at chromosome 8p21.3-22. Faseb J 17: 1180\u00e2\u0080\u00931182."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB39","unstructured":"Sekiya T , Oda T , Matsuura K & Akiyama T (2004) Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling. Biochem Biophys Res Commun 320: 680\u00e2\u0080\u0093684."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB40","unstructured":"Shirin H , Sordillo EM , Kolevska TK et al. (2000) Chronic Helicobacter pylori infection induces an apoptosis-resistant phenotype associated with decreased expression of p27(kip1). Infect Immun 68: 5321\u00e2\u0080\u00935328."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB41","unstructured":"Sinner D , Rankin S , Lee M & Zorn AM (2004) Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes. Development 131: 3069\u00e2\u0080\u00933080."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB42","doi-asserted-by":"crossref","unstructured":"Sokabe T , Yamamoto K , Ohura N , Nakatsuka H , Qin K , Obi S , Kamiya A & Ando J (2004) Differential regulation of urokinase-type plasminogen activator expression by fluid shear stress in human coronary artery endothelial cells. Am J Physiol Heart Circ Physiol 287: 2027\u00e2\u0080\u00932034.","DOI":"10.1152\/ajpheart.00260.2004"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB43","doi-asserted-by":"crossref","unstructured":"ten Dijke P , Korchynskyi O , Valdimarsdottir G & Goumans MJ (2003) Controlling cell fate by bone morphogenetic protein receptors. Mol Cell Endocrinol 211: 105\u00e2\u0080\u0093113.","DOI":"10.1016\/j.mce.2003.09.016"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB44","doi-asserted-by":"crossref","unstructured":"Thompson SA , Wang LL & Sparling PF (1993a) Cloning and nucleotide sequence of frpC, a second gene from Neisseria meningitidis encoding a protein similar to RTX cytotoxins. Mol Microbiol 9: 85\u00e2\u0080\u009396.","DOI":"10.1111\/j.1365-2958.1993.tb01671.x"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB45","doi-asserted-by":"crossref","unstructured":"Thompson SA , Wang LL , West A & Sparling PF (1993b) Neisseria meningitidis produces iron-regulated proteins related to the RTX family of exoproteins. J Bacteriol 175: 811\u00e2\u0080\u0093818.","DOI":"10.1128\/jb.175.3.811-818.1993"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB46","doi-asserted-by":"crossref","unstructured":"Topper JN , Cai J , Qiu Y et al. (1997) Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc Natl Acad Sci USA 94: 9314\u00e2\u0080\u00939319.","DOI":"10.1073\/pnas.94.17.9314"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB47","doi-asserted-by":"crossref","unstructured":"Wasserman SM , Mehraban F , Komuves LG , Yang RB , Tomlinson JE , Zhang Y , Spriggs F & Topper JN (2002) Gene expression profile of human endothelial cells exposed to sustained fluid shear stress. Physiol Genomics 12: 13\u00e2\u0080\u009323.","DOI":"10.1152\/physiolgenomics.00102.2002"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB48","doi-asserted-by":"crossref","unstructured":"Welch RA (2001) RTX toxin structure and function: a story of numerous anomalies and few analogies in toxin biology. Curr Top Microbiol Immunol 257: 85\u00e2\u0080\u0093111.","DOI":"10.1007\/978-3-642-56508-3_5"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB49","doi-asserted-by":"crossref","unstructured":"Wells DB , Tighe PJ , Wooldridge KG , Robinson K & Ala' Aldeen DA (2001) Differential gene expression during meningeal-meningococcal interaction: evidence for self-defense and early release of cytokines and chemokines. Infect Immun 69: 2718\u00e2\u0080\u00932722.","DOI":"10.1128\/IAI.69.4.2718-2722.2001"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB50","doi-asserted-by":"crossref","unstructured":"Wilson R , Dowling RB & Jackson AD (1996) The biology of bacterial colonization and invasion of the respiratory mucosa. Eur Respir J 9: 1523\u00e2\u0080\u00931530.","DOI":"10.1183\/09031936.96.09071523"},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB51","unstructured":"Zamurovic N , Cappellen D , Rohner D & Susa M (2004) Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity. J Biol Chem 279: 37704\u00e2\u0080\u009337715."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB52","unstructured":"Zavadil J , Cermak L , Soto-Nieves N & Bottinger EP (2004) Integration of TGF-beta\/Smad and Jagged1\/Notch signalling in epithelial-to-mesenchymal transition. EMBO J 23: 1155\u00e2\u0080\u00931165."},{"key":"10.1111\/j.1574-6968.2006.00407.x-BIB53","doi-asserted-by":"crossref","unstructured":"Zhao B , Bowden RA , Stavchansky SA & Bowman PD (2001) Human endothelial cell response to gram-negative lipopolysaccharide assessed with cDNA microarrays. Am J Physiol Cell Physiol 281: C1587\u00e2\u0080\u0093C1595.","DOI":"10.1152\/ajpcell.2001.281.5.C1587"}],"container-title":["FEMS Microbiology Letters"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femsle\/article-pdf\/263\/1\/109\/19426957\/263-1-109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T15:07:56Z","timestamp":1683558476000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femsle\/article-lookup\/doi\/10.1111\/j.1574-6968.2006.00407.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,10]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1574-6968.2006.00407.x","relation":{},"ISSN":["0378-1097","1574-6968"],"issn-type":[{"value":"0378-1097","type":"print"},{"value":"1574-6968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10]]}}}