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Recently, miRNAs have emerged as a new class of molecules in response to hypoxia. We show here that the expression of microRNA\u2010210 (mir\u2010210) is up\u2010regulated in patients with pre\u2010eclampsia, as well as in trophoblast cells cultured under hypoxic conditions. Ectopic expression of mir\u2010210 inhibited the migration and invasion capability of trophoblast cells. Ephrin\u2010A3 and Homeobox\u2010A9, which related with cell migration and vascular remodelling, were then experimentally validated as the functional targets of mir\u2010210 both <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. Using luciferase reporter, chromatin immunoprecipitation (ChIP) and small interfering RNA (siRNA) experiments, we finally identified a new transcriptional mechanism that the overexpression of mir\u2010210 under hypoxia was regulated by NF\u2010\u03baB transcriptional factor p50, apart from the well\u2010known HIF 1\u03b1. Taken together, our study implicates an important role for mir\u2010210 in the molecular mechanism of pre\u2010eclampsia.<\/jats:p>","DOI":"10.1111\/j.1582-4934.2011.01291.x","type":"journal-article","created":{"date-parts":[[2011,3,9]],"date-time":"2011-03-09T15:24:30Z","timestamp":1299684270000},"page":"249-259","source":"Crossref","is-referenced-by-count":198,"title":["Elevated levels of hypoxia\u2010inducible microRNA\u2010210 in pre\u2010eclampsia: new insights into molecular mechanisms for the 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