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It includes hallucinations, delusions including paranoia, aggressive behaviour, apathy and other psychotic phenomena that occur in a wide range of degenerative disorders including Alzheimer\u2019s disease, synucleinopathies (Parkinson\u2019s disease, dementia with Lewy bodies), Huntington\u2019s disease, frontotemporal degenerations, motoneuron and prion diseases. Many of these psychiatric manifestations may be early expressions of cognitive impairment, but often there is a dissociation between psychotic\/behavioural symptoms and the rather linear decline in cognitive function, suggesting independent pathophysiological mechanisms. Strictly neuropathological explanations are likely to be insufficient to explain them, and a large group of heterogeneous factors (environmental, neurochemical changes, genetic factors, etc.) may influence their pathogenesis. Clinico\u2010pathological evaluation of behavioural and psychotic symptoms (PS) in the setting of neurodegenerative and dementing disorders presents a significant challenge for modern neurosciences. Recognition and understanding of these manifestations may lead to the development of more effective preventive and therapeutic options that can serve to delay long\u2010term progression of these devastating disorders and improve the patients\u2019 quality of life. A better understanding of the pathophysiology and distinctive pathological features underlying the development of PS in neurodegenerative diseases may provide important insights into psychotic processes in general.<\/jats:p>","DOI":"10.1111\/j.1582-4934.2011.01311.x","type":"journal-article","created":{"date-parts":[[2011,3,21]],"date-time":"2011-03-21T19:22:43Z","timestamp":1300735363000},"page":"995-1012","source":"Crossref","is-referenced-by-count":45,"title":["Cerebral correlates of psychotic syndromes in neurodegenerative diseases"],"prefix":"10.1111","volume":"16","author":[{"given":"Kurt A.","family":"Jellinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,26]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"Wikipedia. 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