{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T16:01:50Z","timestamp":1720281710208},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T00:00:00Z","timestamp":1335398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Up\u2010regulation of insulin\u2010like growth factor 2 receptor (IGF\u20102R) involved in angiotensin II\u2013induced cell apoptosis in cardiomyoblasts, and correlated with cardiomyocyte apoptosis in hypertensive rat hearts. Here, we detected IGF\u20102R levels and explored the possible underlying implications in end\u2010stage heart failure (HF) patients before and after heart transplantation. Western blot and immunohistochemistry were used to measure cardiac IGF\u20102R levels. ELISA was used to detect serum IGF\u20102R and CD8 levels. Labelling of DNA strand breaks and dihydroethidium detection were used to determine cellular apoptosis and reactive oxygen species, respectively. Cardiac IGF\u20102R levels increased in end\u2010stage HF patients (<jats:italic>n<\/jats:italic> = 11) compared with non\u2010failing control subjects. Leu27\u2010IGF\u20102, an IGF\u20102 analogue to activate specially the IGF\u20102R, could induce apoptosis and reactive oxygen species production in neonatal rat ventricular myocytes. The serum IGF\u20102R levels were significantly higher in HF patients than those in non\u2010failing control subjects. An unexpected observation is that the serum IGF\u20102R levels further increased after heart transplantation, peaked at the first month, and gradually reduced close to the levels before heart transplantation at the 6th months after heart transplantation. Serum CD8, a marker of acute rejection, had no change after heart transplantation, but IGF\u20102R and Granzyme B, as a ligand for the IGF\u20102R and a marker for CD8 T lymphocyte activation, coexisted in the transplanted hearts. Our preliminary studies suggest that elevation of IGF\u20102R may participate in pathological process of end\u2010stage HF and involved in the acute cellular rejection after heart transplantation.<\/jats:p>","DOI":"10.1111\/j.1582-4934.2011.01414.x","type":"journal-article","created":{"date-parts":[[2011,9,7]],"date-time":"2011-09-07T03:48:31Z","timestamp":1315367311000},"page":"1038-1046","source":"Crossref","is-referenced-by-count":9,"title":["Elevation of IGF\u20102 receptor and the possible underlying implications in end\u2010stage heart failure patients before and after heart transplantation"],"prefix":"10.1111","volume":"16","author":[{"given":"Yingjie","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanjue","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yishi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengshou","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,26]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2730-05.2006"},{"key":"e_1_2_8_3_2","first-page":"591","article-title":"Mannose 6\u2010phosphate\/insulin\u2010like growth factor II receptor mediates the growth\u2010inhibitory effects of retinoids","volume":"10","author":"Kang JX","year":"1999","journal-title":"Cell Growth Differ."},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.35.24685"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)69101-X"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.2.580"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.6.1389"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-5-15"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1677\/JME-08-0051"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1080350415"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.24.2953"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015514324328"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-07-0619"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00127.2005"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00140-9"},{"key":"e_1_2_8_16_2","first-page":"587","article-title":"A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. 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