{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:49:32Z","timestamp":1792507772086,"version":"4.5.0"},"reference-count":72,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T00:00:00Z","timestamp":1335398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intermittent hypobaric hypoxia (<jats:styled-content style=\"fixed-case\">IHH<\/jats:styled-content>) has been the focus of important research in cardioprotection, and it has been associated with several mechanisms. Intermittent hypobaric hypoxia inhibits prolyl hydroxylases (<jats:styled-content style=\"fixed-case\">PHD<\/jats:styled-content>) activity, increasing the stabilization of hypoxia\u2010inducible factor\u20101 (<jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\u20101) and activating crucial adaptative genes. It has been hence suggested that <jats:styled-content style=\"fixed-case\">IHH<\/jats:styled-content> might be a simple intervention, which may offer a thoughtful benefits to patients with acute myocardial infarction and no complications. Nevertheless, several doubts exist as to whether <jats:styled-content style=\"fixed-case\">IHH<\/jats:styled-content> is a really safe technique, with little to no complications in post\u2010myocardial infarction patients. Intermittent hypobaric hypoxia might produce instead unfavourable changes such as impairment of vascular hemodynamics and hypertensive response, increased risk of hemoconcentration and thrombosis, cardiac rhythm perturbations, coronary artery disease and heart failure, insulin resistance, steatohepatitis and even high\u2010altitude pulmonary oedema in susceptible or nonacclimatized patients. Although intermittent and chronic exposures seem effective in cardioprotection, <jats:styled-content style=\"fixed-case\">IHH<\/jats:styled-content> safety issues have been mostly overlooked, so that assorted concerns should be raised about the opportunity to use <jats:styled-content style=\"fixed-case\">IHH<\/jats:styled-content> in the post\u2010myocardial infarction period. Several <jats:styled-content style=\"fixed-case\">IHH<\/jats:styled-content> protocols used in some studies were also aggressive, which would hamper their widespread introduction within the clinical practice. As such, further research is needed before <jats:styled-content style=\"fixed-case\">IHH<\/jats:styled-content> can be widely advocated in myocardial infarction prevention and recovery.<\/jats:p>","DOI":"10.1111\/j.1582-4934.2011.01508.x","type":"journal-article","created":{"date-parts":[[2011,12,12]],"date-time":"2011-12-12T14:42:55Z","timestamp":1323700975000},"page":"1150-1154","source":"Crossref","is-referenced-by-count":16,"title":["Intermittent hypobaric hypoxia applicability in myocardial infarction prevention and recovery"],"prefix":"10.1111","volume":"16","author":[{"given":"Fabian","family":"Sanchis\u2010Gomar","sequence":"first","affiliation":[{"name":"Faculty of Medicine Department of Physiology University of Valencia Valencia Spain"},{"name":"Fundaci\u00f3n Investigaci\u00f3n Hospital Cl\u00ednico Universitario\/INCLIVA Valencia 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