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In the last years, it has been demonstrated that modulatory treatments for brain repair such as trophic factor\u2010 and stem cell\u2010based therapies can promote neurogenesis, gliogenesis, oligodendrogenesis, synaptogenesis and angiogenesis, all of which having a beneficial impact on infarct volume, cell death and, finally, and most importantly, on the functional recovery. However, even when promising results have been obtained in a wide range of experimental animal models and conditions these preliminary results have not yet demonstrated their clinical efficacy. Here, we focus on brain repair modulatory treatments for ischaemic stroke, that use trophic factors, drugs with trophic effects and stem cell therapy. Important and still unanswered questions for translational research ranging from experimental animal models to recent and ongoing clinical trials are reviewed here.<\/jats:p>","DOI":"10.1111\/j.1582-4934.2012.01575.x","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T14:07:53Z","timestamp":1332857273000},"page":"2280-2290","source":"Crossref","is-referenced-by-count":49,"title":["Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke"],"prefix":"10.1111","volume":"16","author":[{"given":"Mar\u00eda","family":"Guti\u00e9rrez\u2010Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Neurology and Stroke Centre La Paz University Hospital Neuroscience Area of IdiPAZ (Health Research Institute) Aut\u00f3noma University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Fuentes","sequence":"additional","affiliation":[{"name":"Neuroscience and 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