{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:56:57Z","timestamp":1790355417009,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Stem cell therapy is a new strategy for chronic ischaemic heart disease in patients. However, no consensus exists on the most optimal delivery strategy. This randomized study was designed to assess cell delivery efficiency of three clinically relevant strategies: intracoronary (<jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>) and transendocardial (<jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>) using electromechanical mapping guidance (<jats:styled-content style=\"fixed-case\">NOGA<\/jats:styled-content>) compared to surgical delivery in a chronic pig model of ischaemic cardiomyopathy. Twenty\u2010four animals underwent delivery of 10<jats:sup>7<\/jats:sup> autologous Indium\u2010oxine\u2010labelled bone marrow\u2010derived mesenchymal stem cells (<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>) 4\u00a0weeks after infarction and were randomized to one of three groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a08 each group): <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TE<\/jats:styled-content> or surgical delivery (reference group). Primary endpoint was defined as percentage (%) of injected dose per organ and assessed by <jats:italic>in vivo<\/jats:italic> gamma\u2010emission counting. In addition, troponin and coronary flow were assessed before and after <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content> injection. Blinded endpoint analysis showed no significant difference in efficiency after surgical (16\u00a0\u00b1\u00a04%), <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content> (11\u00a0\u00b1\u00a01%) and <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> (11\u00a0\u00b1\u00a03%) (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.52) injections. <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content> showed less variability in efficiency compared with <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> and surgical injection. Overall, <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> injection showed less distribution of <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content> to visceral organs compared with other modalities. Troponin rise and <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content> flow did not differ between the percutaneous groups. This randomized study showed no significant difference in cell delivery efficiency to the myocardium in a clinically relevant ischaemic large animal model between <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> delivery. In addition, no differences in safety profile were observed. These results are important in view of the choice of percutaneous cell delivery modality in future clinical stem cell trials.<\/jats:p>","DOI":"10.1111\/j.1582-4934.2012.01594.x","type":"journal-article","created":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T18:07:42Z","timestamp":1339697262000},"page":"2768-2776","source":"Crossref","is-referenced-by-count":51,"title":["Transendocardial cell injection is not superior to intracoronary infusion in a porcine model of ischaemic cardiomyopathy: a study on delivery efficiency"],"prefix":"10.1111","volume":"16","author":[{"given":"Tycho I.G.","family":"van der Spoel","sequence":"first","affiliation":[{"name":"Division Heart and Lungs Department of Cardiology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krijn R.","family":"Vrijsen","sequence":"additional","affiliation":[{"name":"Division Heart and Lungs Department of Cardiology University Medical Center 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