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We have previously shown that<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u03b2 and calcium deposition, and \u03b2\u2010secretase activity, are robustly increased in the ipsilateral thalamus after transient middle cerebral artery occlusion (<jats:styled-content style=\"fixed-case\">MCAO<\/jats:styled-content>) in rats. Here, we investigated whether the non\u2010selective calcium channel blocker bepridil, which also inhibits \u03b2\u2010secretase cleavage of<jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>, affects thalamic accumulation of<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u03b2 and calcium and in turn influences functional recovery in rats subjected to<jats:styled-content style=\"fixed-case\">MCAO<\/jats:styled-content>. A 27\u2010day bepridil treatment (50\u00a0mg\/kg, p.o.) initiated 2\u00a0days after<jats:styled-content style=\"fixed-case\">MCAO<\/jats:styled-content>significantly decreased the levels of soluble<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u03b240,<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u03b242 and calcium in the ipsilateral thalamus, as compared with vehicle\u2010treated<jats:styled-content style=\"fixed-case\">MCAO<\/jats:styled-content>rats. Expression of seladin\u20101\/DHCR24 protein, which is a potential protective factor against neuronal damage, was decreased at both<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>and protein levels in the ipsilateral thalamus of<jats:styled-content style=\"fixed-case\">MCAO<\/jats:styled-content>rats. Conversely, bepridil treatment restored seladin\u20101\/DHCR24 expression in the ipsilateral thalamus. Bepridil treatment did not significantly affect heme oxygenase\u20101\u2010 or NAD(P)H quinone oxidoreductase\u20101\u2010mediated oxidative stress or inflammatory responses in the ipsilateral thalamus of<jats:styled-content style=\"fixed-case\">MCAO<\/jats:styled-content>rats. Finally, bepridil treatment mitigated<jats:styled-content style=\"fixed-case\">MCAO<\/jats:styled-content>\u2010induced alterations in<jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>processing in the ipsilateral thalamus and improved contralateral forelimb use in<jats:styled-content style=\"fixed-case\">MCAO<\/jats:styled-content>rats. These findings suggest that bepridil is a plausible therapeutic candidate in<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>or stroke owing to its multifunctional role in key cellular events that are relevant for the pathogenesis of these diseases.<\/jats:p>","DOI":"10.1111\/j.1582-4934.2012.01599.x","type":"journal-article","created":{"date-parts":[[2012,7,14]],"date-time":"2012-07-14T15:29:29Z","timestamp":1342279769000},"page":"2754-2767","source":"Crossref","is-referenced-by-count":21,"title":["Bepridil decreases<scp>A<\/scp>\u03b2 and calcium levels in the thalamus after middle cerebral artery occlusion in rats"],"prefix":"10.1111","volume":"16","author":[{"given":"Timo","family":"Saraj\u00e4rvi","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine \u2013 Neurology University of Eastern Finland Kuopio 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