{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:58:00Z","timestamp":1761764280828},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,7,5]],"date-time":"2004-07-05T00:00:00Z","timestamp":1088985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> We examined the relationships between long\u2010term treatment response, side\u2010effects and drug discontinuation in panic disorder (PD)\u2013agoraphobia.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> A total of 326 patients were naturalistically treated with antidepressants and followed for a period of 3\u2003years. All patients were evaluated by means of the Panic Disorder\/Agoraphobia Interview and the Longitudinal Interview Follow\u2010up Examination (LIFE\u2010UP).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> A total of 179 patients interrupted pharmacological treatment. Among them, 26.8% were not traceable; 36.9% had deemed further contact with the psychiatrist unnecessary because of remission. Other reasons for interruption were: ineffectiveness (18.4%), side\u2010effects (10.6%) and personal reasons (7.3%). Patients who interrupted pharmacological treatment because of symptom remission remained in the study for a longer period than those patients who interrupted their treatment because of inefficacy.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> In the long\u2010term treatment of PD with antidepressants, a high percentage of patients who have achieved symptom remission tend to default from further treatment; adherence to long\u2010term treatment with antidepressants was predicted by severe and long\u2010lasting symptomatology.<\/jats:p>","DOI":"10.1111\/j.1600-0047.2004.00347.x","type":"journal-article","created":{"date-parts":[[2004,7,5]],"date-time":"2004-07-05T19:10:43Z","timestamp":1089054643000},"page":"130-137","source":"Crossref","is-referenced-by-count":13,"title":["Spontaneous treatment discontinuation in panic disorder patients treated with antidepressants"],"prefix":"10.1111","volume":"110","author":[{"given":"C.","family":"Toni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Perugi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Frare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Mata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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