{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T08:46:50Z","timestamp":1697532410987},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,7,18]],"date-time":"2011-07-18T00:00:00Z","timestamp":1310947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To compare cervical fluid nitric oxide release in women with and without <jats:italic>Chlamydia trachomatis<\/jats:italic> and high\u2010risk human papillomavirus infection (hrHPV). <jats:italic>Design.<\/jats:italic> An open clinical study. <jats:italic>Setting.<\/jats:italic> University Hospital of Helsinki. <jats:italic>Population.<\/jats:italic> Thirty\u2010nine women with (<jats:italic>n<\/jats:italic>=21) and without <jats:italic>C. trachomatis<\/jats:italic> (<jats:italic>n<\/jats:italic>=18). <jats:italic>Methods. Chlamydia trachomatis<\/jats:italic> and\/or hrHPV were studied by using specific RNA\u2010 and DNA\u2010based tests. Levels of cervical fluid nitric oxide metabolite (NOx) were assessed by the Griess reaction. <jats:italic>Main Outcome Measures.<\/jats:italic> The difference in cervical fluid NOx between women with and without <jats:italic>C. trachomatis<\/jats:italic> and hrHPV. <jats:italic>Results.<\/jats:italic> Fourteen (67%) <jats:italic>C. trachomatis<\/jats:italic>\u2010infected women and three (17%) noninfected women had concomitant hrHPV. The level of cervical fluid NOx in women with <jats:italic>C. trachomatis<\/jats:italic> (median 37.5\u03bcmol\/l, 95% confidence interval 26.1\u201350.9) was higher (<jats:italic>p<\/jats:italic>=0.02) than that in <jats:italic>C. trachomatis<\/jats:italic>\u2010noninfected women (median 19.7\u03bcmol\/L, 95% confidence interval 5.6\u201330.0). The presence of hrHPV did not associate with any difference in NOx levels between <jats:italic>C. trachomatis<\/jats:italic>\u2010infected or \u2010noninfected women. <jats:italic>Conclusions. Chlamydia trachomatis<\/jats:italic> was associated with increased release of nitric oxide metabolites in the uterine cervix. This stimulus was stronger than that of hrHPV, because no additional rise in NOx was seen in women with concomitant <jats:italic>C. trachomatis<\/jats:italic> and hrHPV infection.<\/jats:p>","DOI":"10.1111\/j.1600-0412.2011.01205.x","type":"journal-article","created":{"date-parts":[[2011,6,6]],"date-time":"2011-06-06T12:31:12Z","timestamp":1307363472000},"page":"961-965","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cervical nitric oxide release in <i>Chlamydia trachomatis<\/i> and high\u2010risk human papillomavirus 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