{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:08:43Z","timestamp":1767830923303,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,7,18]],"date-time":"2011-07-18T00:00:00Z","timestamp":1310947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To investigate expression of matrix metalloproteinases (MMPs) and the tissue inhibitors of MMPs (TIMPs) at the feto\u2010maternal interface and non\u2010implantation sites in unruptured tubal pregnancies. <jats:italic>Design.<\/jats:italic> Prospective study. <jats:italic>Setting.<\/jats:italic> University teaching hospital. <jats:italic>Population.<\/jats:italic> Eighteen patients with unruptured tubal pregnancy undergoing salpingectomy. <jats:italic>Methods.<\/jats:italic> Immunohistochemistry was used to detect MMP\u20102, \u20109 and \u201014, and TIMP\u20101, \u20102 and \u20103 at the feto\u2010maternal interface and non\u2010implantation regions of the Fallopian tube. Serum levels of human chorionic gonadotropin (\u03b2\u2010hCG) were determined, and trophoblastic invasion was histologiclly classified as stage I when limited to the tubal mucosa and stage II when extending to the muscular layer. <jats:italic>Main Outcome Measures.<\/jats:italic> The relation between serum \u03b2\u2010hCG concentration with the depth of trophoblastic invasion into the tubal wall and differential expression of MMPs and TIMPs. <jats:italic>Results.<\/jats:italic> A significant difference in the \u03b2\u2010hCG concentrations was seen between stage I and II invasion. Immunoreactivity for MMP\u20102, \u20109 and \u201014, and TIMP\u20101, \u20102 and \u20103 was primarily localized to cytotrophoblasts. At the implantation sites, the intensity of MMPs increased along the invasive pathway towards the maternal interstitium. The expression of MMP\u20102, MMP\u201014 and TIMP\u20103 was localized to the epithelium and smooth muscle cells of the Fallopian tube, while expression of MMP\u20109, TIMP\u20101 and TIMP\u20102 was weak or absent. <jats:italic>Conclusions.<\/jats:italic> Human chorionic gonadotropin correlated positively with invasion stage of trophoblasts. At ectopic implantation sites, the expression of MMPs gradually increased with increasing invasion depth of trophoblasts. TIMP\u20101 and TIMP\u20102 were only weakly expressed. The imbalance between expression of MMPs and TIMPs at the ectopic implantation sites may lead to the extensive destructive degradation of the extracellular matrix.<\/jats:p>","DOI":"10.1111\/j.1600-0412.2011.01206.x","type":"journal-article","created":{"date-parts":[[2011,6,6]],"date-time":"2011-06-06T15:06:34Z","timestamp":1307372794000},"page":"966-971","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Expression of matrix metalloproteinases and their inhibitors at the feto\u2010maternal interface in unruptured ectopic tubal pregnancy"],"prefix":"10.1111","volume":"90","author":[{"given":"XIAOYAN","family":"QIU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YI","family":"XIE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LINGLING","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KRISTINA","family":"GEMZELL\u2010DANIELSSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,18]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"249","volume-title":"Current concepts in endometrial receptivity and implantation","author":"Glasser S","year":"2002"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60942-X"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0005"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6408(1997)21:1<44::AID-DVG5>3.0.CO;2-8"},{"key":"e_1_2_8_6_2","first-page":"556","volume-title":"Ectopic pregnancy","author":"Glasser S","year":"2002"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem283"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67103-6"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)04922-1"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200304000-00028"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56994-5"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del170"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.10.036"},{"key":"e_1_2_8_14_2","first-page":"191","article-title":"Simultaneous expression of 70 kilodalton type IV collagenase and type IV collagen alpha 1 (IV) chain genes by cells of early human placenta and gestational endometrium","volume":"67","author":"Autio\u2010Harmainen H","year":"1992","journal-title":"Lab Invest."},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/plac.1999.0447"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/3.8.713"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(05)80454-0"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/44.12.8985130"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(96)80073-7"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2795(199612)45:4<458::AID-MRD8>3.0.CO;2-Q"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002020408"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.136.11.4973"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00283"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0412.2011.01206.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0412.2011.01206.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:05:19Z","timestamp":1697429119000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0412.2011.01206.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,18]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1111\/j.1600-0412.2011.01206.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0412.2011.01206.x","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,18]]},"assertion":[{"value":"2011-07-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}