{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:49:25Z","timestamp":1772160565902,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T00:00:00Z","timestamp":1318291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . To determine the effectiveness of rociverine, an antispasmodic drug, for reducing the duration of labor among nulliparous women managed according to a standard intrapartum protocol.\n                    <jats:italic>Design<\/jats:italic>\n                    . Randomized controlled trial.\n                    <jats:italic>Setting<\/jats:italic>\n                    . An academic tertiary care hospital.\n                    <jats:italic>Population<\/jats:italic>\n                    . Nulliparae in spontaneous active labor, with cervical dilatation between 3 and 5cm.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Participants were randomly assigned to receive either an intramuscular injection of 20mg rociverine (\n                    <jats:italic>n<\/jats:italic>\n                    =55) or the same volume of saline (\n                    <jats:italic>n<\/jats:italic>\n                    =56).\n                    <jats:italic>Main Outcome Measure<\/jats:italic>\n                    . Cervical dilatation rate (from administration of study drug to full dilatation).\n                    <jats:italic>Results<\/jats:italic>\n                    . Laboring women who received rociverine had faster cervical dilatation than those assigned to placebo (2.43\u00b11.84 vs. 1.85\u00b11.38cm\/hour,\n                    <jats:italic>p<\/jats:italic>\n                    =0.03). The time interval from treatment administration to full cervical dilatation was shorter in the rociverine group than in the placebo group (220\u00b1125 vs. 278\u00b1129min,\n                    <jats:italic>p<\/jats:italic>\n                    =0.04). No difference was found in any other obstetric outcome. No adverse effects have been recorded from rociverine administration.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . Intrapartum administration of rociverine to nulliparous women may help to reduce the duration of the first stage of labor in a context of uniform labor management.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0412.2011.01265.x","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T13:35:49Z","timestamp":1314884149000},"page":"1371-1378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Use of an antispasmodic (rociverine) to shorten the length of labor: a randomized, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"90","author":[{"given":"ANTONELLA","family":"CROMI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FABIO","family":"GHEZZI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MASSIMO","family":"AGOSTI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEFANO","family":"UCCELLA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NICOLETTA","family":"PIAZZA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAURIZIO","family":"SERATI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PIERFRANCESCO","family":"BOLIS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181f5eaf0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-536X.1996.tb00475.x"},{"issue":"2","key":"e_1_2_6_4_2","first-page":"CD006794","article-title":"Early amniotomy and early oxytocin for prevention of, or therapy for, delay in first stage spontaneous labour compared with routine care","author":"Wei S","year":"2009","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4001.559-b"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S0022-3565(25)07868-1","article-title":"The action of Syntropan on the uterus","volume":"70","author":"Clark BB","year":"1940","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_7_2","first-page":"564","article-title":"Clinical results with the spasmolytic buscopan in obstetrics","volume":"94","author":"Leuxner E","year":"1952","journal-title":"Munch Med Wochenschr."},{"key":"e_1_2_6_8_2","first-page":"69","article-title":"The use of Buscopan during the first stage of labor","volume":"15","author":"Chan DPC","year":"1963","journal-title":"Hong Kong Med Ass CME Bull."},{"key":"e_1_2_6_9_2","first-page":"382","article-title":"Influence of spasmolytic treatment and amniotomy on delivery times: a factorial clinical trial","volume":"3","author":"Guerresi E","year":"1981","journal-title":"Clin Ther."},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(01)00448-9"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(03)00276-5"},{"key":"e_1_2_6_12_2","first-page":"270","article-title":"Phloroglucinol for acceleration of labour: double blind, randomized controlled trial","volume":"55","author":"Tabassum S","year":"2005","journal-title":"J Pak Med Assoc."},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2005.00359.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01497.x"},{"key":"e_1_2_6_15_2","first-page":"450","article-title":"Study of drotaverine on first stage of labour and pregnancy outcome","volume":"105","author":"Roy A","year":"2007","journal-title":"J Indian Med Assoc"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.08.020"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5359.40982"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.06.021"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-009-1188-8"},{"key":"e_1_2_6_20_2","unstructured":"Available at:http:\/\/www2.cochrane.org\/reviews\/de\/title_34634025958422989498090817153214.html(accessed 19 September 2011)."},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0922-4106(95)90024-1"},{"key":"e_1_2_6_22_2","first-page":"584","article-title":"Mechanism of smooth muscle relaxation by rociverine","volume":"34","author":"D\u2019Agostino G","year":"1984","journal-title":"Arzneimittelforschung."},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1139\/y89-131"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod40.2.209"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90126-9"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e328337c881"},{"key":"e_1_2_6_28_2","first-page":"574","article-title":"Influence of prostaglandins and adrenoceptor agonists on contractile activity in the human cervix at term","volume":"67","author":"Bryman I","year":"1986","journal-title":"Obstet Gynecol."},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-536x.1999.00211.x"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0412.2011.01265.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0412.2011.01265.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T13:11:34Z","timestamp":1741525894000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0412.2011.01265.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,11]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1111\/j.1600-0412.2011.01265.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0412.2011.01265.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13393984.14762093","asserted-by":"object"}]},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,11]]},"assertion":[{"value":"2011-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}