{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:09:24Z","timestamp":1793743764923,"version":"4.6.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T00:00:00Z","timestamp":1318896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic>\u2002To identify maternal\/pregnancy characteristics, first trimester ultrasound parameters and biochemical indices which are significant independent predictors of small\u2010for\u2010gestational age (SGA) and large\u2010for\u2010gestational age (LGA) neonates.\u2002<jats:italic>Design.<\/jats:italic>\u2002Retrospective cross\u2010sectional study.\u2002<jats:italic>Setting.<\/jats:italic>\u2002Two fetal Medicine Units.\u2002<jats:italic>Population.<\/jats:italic>\u20024\u2003702 singleton pregnancies presenting for screening for chromosomal abnormalities by nuchal translucency and maternal serum biochemistry at 11\u201314 weeks.\u2002<jats:italic>Methods.<\/jats:italic>\u2002Reference ranges for birthweight applied to our population were constructed by the Royston and Wright method. Multiple logistic regression was applied to develop first trimester prediction models for SGA and LGA.\u2002<jats:italic>Main outcome measures.<\/jats:italic>\u2002Birth of SGA or LGA neonate.\u2002<jats:italic>Results.<\/jats:italic>\u2002Maternal height, parity, smoking, assisted conception, delta crown\u2013rump length, delta nuchal translucency, free beta human chorionic gonadotrophin and pregnancy\u2010associated plasma protein\u2010A were significant independent predictors of SGA. Maternal weight and height, smoking, delta crown\u2013rump length and delta nuchal translucency were significant independent predictors of LGA. Models for SGA (AUC=0.7296, CI: 0.69\u20130.76,\u2002<jats:italic>p<\/jats:italic>&lt;0.0001) and LGA (AUC=0.6901, CI: 0.65\u20130.72,\u2002<jats:italic>p<\/jats:italic>&lt;0.0001) were derived, applicable to routine obstetric population at low risk for these conditions. For 20% screen positive rate the modeling achieves sensitivities of about 55% for SGA and 48% for LGA neonates.\u2002<jats:italic>Conclusion.<\/jats:italic>\u2002Prediction for birthweight deviations is feasible using data available at the routine 11\u201314 weeks\u2019 examination. Delta CRL and delta nuchal translucency were significant independent predictors for both SGA and LGA.<\/jats:p>","DOI":"10.1111\/j.1600-0412.2011.01271.x","type":"journal-article","created":{"date-parts":[[2011,9,5]],"date-time":"2011-09-05T08:37:35Z","timestamp":1315211855000},"page":"104-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["First trimester prediction of small\u2010 and large\u2010for\u2010gestation neonates by an integrated model incorporating ultrasound parameters, biochemical indices and maternal characteristics"],"prefix":"10.1111","volume":"91","author":[{"given":"IOANNIS","family":"PAPASTEFANOU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ATHENA 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