{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:34:58Z","timestamp":1789522498189,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T00:00:00Z","timestamp":1320796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic>\u2002Although some patients may benefit from reduced follicle\u2010stimulating hormone (FSH) application, in\u2010vitro maturation (IVM) belongs to the rare treatment options in assisted reproduction. We summarize our five\u2010year IVM experience.\u2002<jats:italic>Design.<\/jats:italic>\u2002Retrospective, observational study.\u2002<jats:italic>Setting.<\/jats:italic>\u2002Reproductive Medicine, University Hospital<jats:italic>. Sample.<\/jats:italic>\u2002115 patients with polycystic ovary syndrome (PCOS) as well as patients after ovarian hyperstimulation syndrome (OHSS) from February 2005 to December 2009.\u2002<jats:italic>Material and Methods<\/jats:italic>. Stimulation started between day 3\u201310 of the menstrual cycle and FSH dosage was 125IU\/day over three days. Ovulation was induced on the third day of FSH injection or one day afterwards and oocyte retrieval was performed 33\u201338 hours later. Oocytes were cultivated for 24 hours in IVM medium. Fertilization was carried out one day after oocyte retrieval and embryo transfer two days afterwards.\u2002<jats:italic>Main outcome measures.<\/jats:italic>\u2002Pregnancy rates.\u2002<jats:italic>Results<\/jats:italic>. 115 patients were included and 215 oocyte retrievals (intracytoplasmic sperm injection:\u2002<jats:italic>n<\/jats:italic>=125, 59%; in vitro fertilization:\u2002<jats:italic>n<\/jats:italic>=73, 34.4%) with 177 embryo transfers performed. The main reasons for IVM were: PCOS (71.7%) and OHSS (15.0%). Mean number of oocytes was 8.9\/oocyte retrieval with 5.9 (64%) becoming mature, 2.8 (45.1%) being fertilized and 2.1 transferred. Pregnancy rate per transfer was 15.3% (<jats:italic>n<\/jats:italic>=27) with 13 live births (7.3%), one intrauterine death (0.6%), four miscarriages (2.3%) and nine biochemical pregnancies (5.1%). In 61 cases, fertilized oocytes were frozen and 32 cryotransfers were performed, resulting in three pregnancies.\u2002<jats:italic>Conclusions.<\/jats:italic>\u2002Although the pregnancy rate was low, IVM is very convenient for patients due to low FSH dosages and few appointments at low cost.<\/jats:p>","DOI":"10.1111\/j.1600-0412.2011.01299.x","type":"journal-article","created":{"date-parts":[[2011,10,14]],"date-time":"2011-10-14T03:47:26Z","timestamp":1318564046000},"page":"22-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["In vitro maturation: a five\u2010year experience"],"prefix":"10.1111","volume":"91","author":[{"given":"SABINE","family":"ROESNER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHAEL","family":"VON 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