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We searched the Medline database through March 2011 for relevant case\u2013control and population\u2010based studies on pre\u2010, peri\u2010 and neonatal hazards related to PDD, including autism. We identified 85 studies for this review. Data were extracted systematically and organized according to risk factors related to family history, pregnancy, gestational age, delivery, birth milestones and the neonate's condition at birth. <jats:italic>Results<\/jats:italic>. During the prenatal period, risk factors for PDD were advanced maternal or paternal ages, being firstborn vs. third or later, maternal prenatal medication use and mother's status as foreign born. During the perinatal and neonatal periods, the risk factors for PDD were preterm birth, breech presentation, planned cesarean section, low Apgar scores, hyperbilirubinemia, birth defect and a birthweight small for gestational age. The influence of maternal pre\u2010eclampsia, diabetes, vomiting, infections and stress during pregnancy requires further study in order to determine risk for PDD. <jats:italic>Discussion<\/jats:italic>. Despite evidence for the association of some pre\u2010, peri\u2010 and neonatal risk factors associated with PDD, it remains unclear whether these risks are causal or play a secondary role in shaping clinical expression in individuals with genetic vulnerability. A plausible hypothsesis is that improvements in obstetric and neonatal management have led to an increased rate of survivors with pre\u2010existing brain damage. Given the variety of risk factors, we propose that future studies should investigate combinations of multiple factors, rather than focusing on a single factor.<\/jats:p>","DOI":"10.1111\/j.1600-0412.2011.01325.x","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T18:42:49Z","timestamp":1321468969000},"page":"287-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":222,"title":["Pre\u2010, peri\u2010 and neonatal risk factors for autism"],"prefix":"10.1111","volume":"91","author":[{"given":"VINCENT","family":"GUINCHAT","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"POUL","family":"THORSEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CLAUDINE","family":"LAURENT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTINE","family":"CANS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NICOLAS","family":"BODEAU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAVID","family":"COHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,21]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"1","article-title":"Prevalence of autism spectrum disorders \u2014 Autism and Developmental Disabilities Monitoring Network, United States, 2006","volume":"58","author":"Autism and Developmental Disabilities Monitoring Network Surveillance Year 2006 Principal Investigators; Centers for Disease Control and Prevention (CDC)","year":"2009","journal-title":"MMWR Surveill Summ."},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.112.8.613"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700028099"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.159.1.37"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.162.12.1150"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.7.945"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2007.00102.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2006.08.005"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-004-1038-2"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.80"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10882-007-9054-8"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01531816"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02172829"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.161.4.326"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.051672"},{"key":"e_1_2_8_17_2","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_8_18_2","volume-title":"The ICD\u201010 classification of mental and behavioural disorders. 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