{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:01:04Z","timestamp":1793145664245,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T00:00:00Z","timestamp":1326931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract\u2002<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To examine the association between maternal obesity and infant mortality, while including information about mode of delivery and interpregnancy weight change. <jats:italic>Design.<\/jats:italic> Register\u2010based cohort study. <jats:italic>Setting and population.<\/jats:italic> A total of 1 199 183 singletons, including 3481 infant deaths, from the Swedish Birth Register 1992\u20132006. <jats:italic>Methods.<\/jats:italic> Maternal body mass index (BMI) was obtained from self\u2010reports in early pregnancy and categorized as underweight (&lt;18.5 kg\/m<jats:sup>2<\/jats:sup>), normal\u2010weight (18.5\u201324.9 kg\/m<jats:sup>2<\/jats:sup>), overweight (25\u201329.9 kg\/m<jats:sup>2<\/jats:sup>), obese (30\u201334.9 kg\/m<jats:sup>2<\/jats:sup>) and extremely obese (\u226535 kg\/m<jats:sup>2<\/jats:sup>). Cox regression was used to estimate hazard ratios (95% confidence intervals). Infants of normal\u2010weight women were the referent. <jats:italic>Main outcome measures.<\/jats:italic> Neonatal and infant mortality. <jats:italic>Results.<\/jats:italic> Infant mortality increased with increasing maternal fatness [adjusted hazard ratios 1.2 (1.1\u20131.3), 1.4 (1.2\u20131.6) and 2.1 (1.8\u20132.5) for overweight, obesity and extreme obesity, respectively]. When accounting for mode of delivery, neonatal mortality was increased in infants of obese and extremely obese mothers after spontaneous births [adjusted hazard ratios 1.8 (1.4\u20132.4) and 2.6 (1.8\u20134.0), respectively, after term births, and 1.4 (1.1\u20131.9) and 2.2 (1.5\u20133.3), respectively, after preterm births]. No excess risk was present for infants of obese mothers after induced term and preterm births (<jats:italic>p<\/jats:italic>\u2010values for interaction &lt;0.05). For post\u2010neonatal mortality, no interaction between mode of delivery and maternal obesity was observed. In women with two subsequent pregnancies, high interpregnancy weight change &gt;1 BMI unit (1 kg\/m<jats:sup>2<\/jats:sup>) seemed to involve a modest increase in neonatal mortality in the second infant, but only after spontaneous births [adjusted odds ratio 1.3 (0.9\u20131.7)]. <jats:italic>Conclusions.<\/jats:italic> Maternal obesity, especially at levels that may involve cardiometabolic morbidity, was associated with increased mortality in the offspring.<\/jats:p>","DOI":"10.1111\/j.1600-0412.2011.01331.x","type":"journal-article","created":{"date-parts":[[2011,11,30]],"date-time":"2011-11-30T10:31:45Z","timestamp":1322649105000},"page":"363-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Mortality in infants of obese mothers: is risk modified by mode of delivery?"],"prefix":"10.1111","volume":"91","author":[{"given":"ELLEN A.","family":"NOHR","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EDUARDO","family":"VILLAMOR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHAEL","family":"VAETH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JORN","family":"OLSEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SVEN","family":"CNATTINGIUS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,19]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh277"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116620"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000172422.81496.57"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.113"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000107291.46159.00"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801670"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.441"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.6.1750"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.91.3.436"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181878645"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00437.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000286760.46679.f8"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der052"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69473-7"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1808"},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1093\/ajcn\/72.5.1186","article-title":"Prenatal compared with parental origins of adolescent fatness","volume":"72","author":"Frisancho AR","year":"2000","journal-title":"Am J Clin Nutr."},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem219"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803741"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6635.1495"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/52.2.273"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/140349489001800209"},{"key":"e_1_2_7_23_2","volume-title":"Obesity: preventing and managing the global epidemic. 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