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Precise estimates of COC\u2010related adverse mood symptoms are not available due to the lack of placebo\u2010controlled trials. In prospective trials the frequency of women who report deteriorated mood or deteriorated emotional well\u2010being varies between 4 and 10%, but it can be assumed that the causal relation in these prevalence rates is overestimated. Adverse mood symptoms and somatic symptoms are most pronounced during the pill\u2010free interval of the treatment cycles, but whether extended COC regimens would be more favorable in this respect is not known. COCs with anti\u2010androgenic progestagens, such as drospirenone and desogestrel, appear more favorable in terms of mood symptoms than progestagens with a more androgenic profile. 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