{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:33:35Z","timestamp":1792809215456,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T00:00:00Z","timestamp":1327536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract\u2002<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To evaluate pregnancy rates with letrozole and clomiphene citrate (CC) alone for superovulation in an intrauterine insemination program for women with recently surgically treated minimal to mild endometriosis. <jats:italic>Design.<\/jats:italic> A randomized controlled trial following the CONSORT criteria. <jats:italic>Setting.<\/jats:italic> University teaching hospital and a private practice setting. <jats:italic>Patients.<\/jats:italic> 136 women with primary infertility due to minimal to mild endometriosis who did not achieve pregnancy after six to 12 months following laparoscopic treatment. <jats:italic>Interventions:<\/jats:italic> Superovulation using 5mg letrozole\/day (69 women, 220 cycles) or 100mg CC\/day (67 women, 213 cycles) for five days combined with intrauterine insemination up to four cycles. <jats:italic>Main outcome measures.<\/jats:italic> Clinical pregnancy rate per cycle, cumulative pregnancy rate after four cycles, number of follicles, serum estradiol, endometrial thickness on the day of human chorionic gonadotropin administration, serum progesterone, miscarriage and live birth rates. <jats:italic>Results.<\/jats:italic> The clinical pregnancy rate per cycle and the cumulative pregnancy rate after four cycles were comparable (15.9 vs. 14.5% and 64.7 vs. 57.2%; <jats:italic>p<\/jats:italic>=0.82, <jats:italic>p<\/jats:italic>=0.71 in letrozole and CC groups, respectively). Two twin pregnancies occurred in the CC\/intrauterine insemination group. Miscarriage and live birth rates were comparable (11.4 vs. 12.9% and 44.9 vs. 40.3%; <jats:italic>p<\/jats:italic>=0.47, <jats:italic>p<\/jats:italic>=0.62 in letrozole and CC groups, respectively). The total number of follicles and serum estradiol on the day of human chorionic gonadotropin administration were significantly increased in the CC group. <jats:italic>Conclusions.<\/jats:italic> Superovulation with letrozole is not more effective than clomiphene citrate alone in an intrauterine insemination program for women with minimal to mild endometriosis who did not achieve pregnancy after six to 12 months following laparoscopic treatment. ClinicalTrials.gov ID: NCT01334762.<\/jats:p>","DOI":"10.1111\/j.1600-0412.2011.01346.x","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T02:08:28Z","timestamp":1324346908000},"page":"338-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Expression of Concern: Randomized comparison of superovulation with letrozole vs. clomiphene citrate in an IUI program for women with recently surgically treated minimal to mild endometriosis"],"prefix":"10.1111","volume":"91","author":[{"given":"HATEM","family":"ABU HASHIM","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MOHAMED","family":"EL RAKHAWY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IBRAHIM","family":"ABD ELAAL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,26]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1000274"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e3181db7bde"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.02.093"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707243370401"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.5.1332"},{"key":"e_1_2_7_7_2","first-page":"CD001398","article-title":"Laparoscopic surgery for subfertility associated with endometriosis","volume":"1","author":"Jacobson TZ","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.01.044"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03343-5"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901213400302"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp003"},{"key":"e_1_2_7_12_2","first-page":"CD005356","article-title":"Ovarian stimulation protocols (anti\u2010oestrogens, gonadotrophins with and without GnRH agonists\/antagonists) for intrauterine insemination (IUI) in women with subfertility","volume":"2","author":"Cantineau AE","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-006-9097-2"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2009.06.008"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e32833beebf"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)81391-X"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016349709024582"},{"key":"e_1_2_7_18_2","volume-title":"Clinical Guideline 11","author":"National Collaborating Centre for Women's and Children's Health \/ National Institue for Clinical Excellence","year":"2004"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.09.045"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.02.070"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01705-2"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-008-0714-4"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.06.052"},{"key":"e_1_2_7_24_2","first-page":"CD006942","article-title":"Synchronised approach for intrauterine insemination in subfertile couples","volume":"4","author":"Cantineau AE","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_25_2","first-page":"CD004507","article-title":"Semen preparation techniques for intrauterine insemination","volume":"4","author":"Boomsma CM","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.07.230"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.03.014"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016340802638199"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq313"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del113"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.07.1051"}],"updated-by":[{"DOI":"10.1111\/aogs.14872","type":"expression_of_concern","label":"Expression of concern","source":"publisher","updated":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000}}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0412.2011.01346.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0412.2011.01346.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T06:59:54Z","timestamp":1714633194000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0412.2011.01346.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,26]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1600-0412.2011.01346.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0412.2011.01346.x","archive":["Portico"],"relation":{"expression_of_concern":[{"id-type":"doi","id":"10.1111\/aogs.14872","asserted-by":"object"}]},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,26]]},"assertion":[{"value":"2012-01-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}