{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:07:15Z","timestamp":1770739635917,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T00:00:00Z","timestamp":1329868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract\u2002<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic> To evaluate the safety of different regimes of thromboprophylaxis with low molecular weight heparins (LMWHs) in women undergoing cesarean section. <jats:italic>Design:<\/jats:italic> Retrospective single\u2010center cross\u2010sectional study. <jats:italic>Setting:<\/jats:italic> University Medical Center, The Netherlands. <jats:italic>Population:<\/jats:italic> All women that delivered by cesarean section in the Erasmus Medical Center, Rotterdam, between January 2004 and December 2007 received thromboprophylaxis. We included women who received thromboprophylaxis according to the routine administration schedule at that time. <jats:italic>Methods:<\/jats:italic> Three different consecutive regimes of thromboprophylaxis were used. In the first period, women received dalteparin 5000IU pre\u2010 and postoperatively (group A), in the second period, nadroparin 5700IU was administered pre\u2010 and postoperatively (group B), and in the third period, nadroparin 2850IU was administered not earlier than 6\u201312 hours postoperatively (group C). Detailed information on individual characteristics, cesarean section and postpartum period were extracted from patient files. <jats:italic>Main outcome measures:<\/jats:italic> Postoperative bleeding complications. <jats:italic>Results:<\/jats:italic> A total of 1527 women were eligible and included. In group B, significantly more women experienced bleeding complications (necessitating either conservative treatment or re\u2010laparotomy) compared with the other two groups (19\/574 women in group B vs. 9\/647 in group A and 1\/306 in group C). After adjusting for potential confounders (maternal age, body mass index, and occurrence of preeclampsia\/hemolysis, elevated liver enzymes and low platelet count) these effects remained significant (<jats:italic>p<\/jats:italic>=0.005). The incidence of thromboembolism was not different in the three groups. <jats:italic>Conclusions:<\/jats:italic> Different regimes of thromboprophylaxis in women with cesarean section influenced the occurrence of bleeding complications.<\/jats:p>","DOI":"10.1111\/j.1600-0412.2012.01351.x","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T07:54:56Z","timestamp":1326182096000},"page":"560-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Thrombophylaxis and bleeding complications after cesarean section"],"prefix":"10.1111","volume":"91","author":[{"given":"CLAUDIA A.","family":"SNIJDER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JER\u00d4ME M.W.","family":"CORNETTE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WIM C.J.","family":"HOP","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIEKE J.H.A.","family":"KRUIP","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHANNES J.","family":"DUVEKOT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,22]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10265-9"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2001.00004.x"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.11.008"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3552(97)80024-7"},{"key":"e_1_2_9_6_2","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1055\/s-0037-1616738","article-title":"Thromboprophylaxis following caesarean section \u2013 a comparison of the antithrombotic properties of three low molecular weight heparins \u2013 dalteparin, enoxaparin and tinzaparin","volume":"86","author":"Ellison J","year":"2001","journal-title":"Thromb Haemost."},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043452811"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0761"},{"key":"e_1_2_9_9_2","unstructured":"Royal College of Obstetricians and Gynaecologists.Thromboprophylaxis during pregnancy labour and after vaginal delivery.2004; Guideline No. 37. Available online at:http:\/\/www.blackwellpublishing.com\/medicine\/bmj\/nnf5\/pdfs\/uk_guidelines\/ENOXAPARIN\u2010thromboprophylaxis_in_pregnancy_guideline.pdf(accessed December 2009)."},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/0144361042331271052"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2001.00198.x"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.039"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"e_1_2_9_14_2","volume-title":"Report of the RCOG working party on prophylaxis against thromboembolism in gynaecology and obstetrics","author":"Royal College of Obstetricians and Gynaecologists","year":"1995"},{"key":"e_1_2_9_15_2","first-page":"19","article-title":"Efficacy and safety of two regimens of low molecular weight heparin fragment (fragmin) in preventing postoperative venous thrombolism","volume":"16","author":"Kakkar VV","year":"1986","journal-title":"Haemostasis."},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-0328(02)00029-0"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02637189"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.08.041"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0412.2012.01351.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0412.2012.01351.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T11:21:37Z","timestamp":1698751297000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0412.2012.01351.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,22]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1600-0412.2012.01351.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0412.2012.01351.x","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,22]]},"assertion":[{"value":"2012-02-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}