{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T11:32:12Z","timestamp":1768303932777,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T00:00:00Z","timestamp":1330905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract\u2002<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. Limited attention has been focused on the medical treatment of bowel endometriosis. This study evaluates the efficacy of administration of a continuous low\u2010dose oral contraceptive in treating pain and other symptoms associated with colorectal endometriotic nodules, as evaluated by rectal endoscopic ultrasonography. <jats:italic>Design.<\/jats:italic> Prospective observational study. <jats:italic>Setting.<\/jats:italic> Academic Department of San Raffaele Scientific Institute, Obstetrics and Gynecology Unit. <jats:italic>Population.<\/jats:italic> Symptomatic women of reproductive age (<jats:italic>n<\/jats:italic>=26) with colorectal nodules infiltrating at least the bowel muscularis propria and without a stenosis &gt;50%. In 31% of the patients, endoscopic ultrasonography permitted diagnosis of nodules located more than 10 cm from the anal rim. <jats:italic>Methods<\/jats:italic>. Patients received a continuous low\u2010dose oral contraceptive containing 15 \u03bcg ethinylestradiol and 60 \u03bcg gestodene for 12 months. Subjective symptoms were prospectively evaluated, and nodule volumes were monitored using endoscopic ultrasonography. <jats:italic>Main outcome measures<\/jats:italic>. Nodule measurements were performed at baseline and after 12 months of treatment. Symptoms at the start and after 12 months were evaluated. <jats:italic>Results<\/jats:italic>. A significant improvement in the intensity of all the considered symptoms (dysmenorrhea, non\u2010menstrual pelvic pain, deep dyspareunia and painful defecation) was seen when evaluated by a visual analog scale. A reduction in terms of both diameter (mean reduction 26%) and volume of the nodules (mean reduction 62%) was observed after a 12 month period. <jats:italic>Conclusions<\/jats:italic>. A continuous low\u2010dose oral contraceptive therapy may reduce bowel endometriosis\u2010associated symptoms. In addition, this therapy induces a significant volumetric reduction of colorectal plaques when evaluated by endoscopic ultrasonography.<\/jats:p>","DOI":"10.1111\/j.1600-0412.2012.01366.x","type":"journal-article","created":{"date-parts":[[2012,1,24]],"date-time":"2012-01-24T05:06:35Z","timestamp":1327381595000},"page":"699-703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Continuous low\u2010dose oral contraceptive in the treatment of colorectal endometriosis evaluated by rectal endoscopic ultrasonography"],"prefix":"10.1111","volume":"91","author":[{"given":"STEFANO","family":"FERRARI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAOLA","family":"PERSICO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FRANCESCA","family":"DI 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