{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:13:51Z","timestamp":1781014431480,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,6,15]],"date-time":"2012-06-15T00:00:00Z","timestamp":1339718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract\u2002<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To assess the neonatal and maternal outcomes of pregnancy complicated by previable preterm premature rupture of membranes (PPROM). <jats:italic>Design.<\/jats:italic> Retrospective study. <jats:italic>Setting.<\/jats:italic> Tertiary referral hospital. <jats:italic>Sample.<\/jats:italic> Forty\u2010five women having aggressive intervention with antibiotics, amnioinfusion, cerclage and tocolysis. <jats:italic>Methods.<\/jats:italic> The hospital database between July 2001 and December 2009 was reviewed for women with singleton fetuses and PPROM before 23<jats:sup>+0<\/jats:sup>\u00a0weeks of gestation. We analysed maternal and neonatal characteristics. <jats:italic>Main outcome measures.<\/jats:italic> Neonatal survival without major morbidity. <jats:italic>Results.<\/jats:italic> Thirty\u2010eight infants were delivered alive and seven were stillborn. Ten infants died in the neonatal intensive care unit and one in the labor ward. Twenty\u2010seven live\u2010born infants survived to discharge from hospital. The survival rate of pregnancies with aggressive management was 60% (27 of 45); that of live\u2010born infants was 71.1% (27 of 38). The median gestational age at PPROM and at delivery were significantly lower in the non\u2010surviving group than the surviving group. Thirty\u2010seven women (82.2%) had an amniotic neutrophil elastase level &gt;0.15\u00a0\u03bcg\/mL. Only four women (8.9%) developed clinical chorioamnionitis. Overall, 90.7% of the women showed histological evidence of chorioamnionitis. Eighty\u2010three per cent of the surviving children had bronchopulmonary dysplasia. Nine infants had serious sequelae at a corrected age of one and a half years. Maternal complications were uncommon. <jats:italic>Conclusions.<\/jats:italic> An aggressive treatment protocol for women with previable PPROM resulted in a high neonatal survival rate. Neonatal survival was associated with higher gestational age at delivery and with more frequent use of antenatal corticosteroids. The prognosis is still bad in PPROM before 22<jats:sup>+0<\/jats:sup>\u00a0weeks of gestation.<\/jats:p>","DOI":"10.1111\/j.1600-0412.2012.01432.x","type":"journal-article","created":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T09:52:04Z","timestamp":1335520324000},"page":"923-929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Aggressive intervention of previable preterm premature rupture of membranes"],"prefix":"10.1111","volume":"91","author":[{"given":"KEN","family":"MIYAZAKI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MADOKA","family":"FURUHASHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KANA","family":"YOSHIDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAORU","family":"ISHIKAWA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,15]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200301000-00033"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(03)00082-4"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0860"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000263888.69178.1f"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(96)80006-1"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.05.047"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.108872"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/01443610600604432"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2004.12.002"},{"key":"e_1_2_7_11_2","first-page":"67","volume-title":"Perinatal diseases. 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