{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T20:04:00Z","timestamp":1767211440233},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,8,15]],"date-time":"2012-08-15T00:00:00Z","timestamp":1344988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> The role of analgesic drug use in development of ovarian cancer is not fully understood. We examined the association between analgesic use and risk of ovarian cancer. In addition, we examined whether the association differed according to histological types. <jats:italic>Design<\/jats:italic>. Population\u2010based case\u2013control study. <jats:italic>Setting.<\/jats:italic> Denmark in the period 1995\u20131999. <jats:italic>Population.<\/jats:italic> We included 756 women with epithelial ovarian cancer and 1564 randomly selected control women aged 35\u201379 years. <jats:italic>Methods.<\/jats:italic> Information on analgesic drug use was collected from personal interviews. Analgesic drugs were divided into the following categories: any analgesics; aspirin; non\u2010aspirin non\u2010steroidal anti\u2010inflammatory drugs; paracetamol; and other analgesic drugs. The association between analgesic drug use and ovarian cancer risk was analysed using multiple logistic regression models. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. <jats:italic>Main outcome measures.<\/jats:italic> Epithelial ovarian cancer. <jats:italic>Results.<\/jats:italic> Women with a regular use of any analgesics (OR = 0.79; 95% CI 0.62 \u2212 1.01) or aspirin (OR = 0.68; 95% CI 0.46 \u2212 1.02) had a decreased risk of ovarian cancer, although not statistically significant. Regular use of non\u2010aspirin non\u2010steroidal anti\u2010inflammatory drugs, paracetamol or other analgesics did not decrease ovarian cancer risk. Use of any analgesics (OR = 0.72; 95% CI 0.53\u20130.98) or aspirin (OR = 0.60; 95% CI 0.36\u20131.00) resulted in a statistically significant decreased risk of serous ovarian cancer but not mucinous or other ovarian tumors. <jats:italic>Conclusion.<\/jats:italic> In accordance with most previous studies, our results indicate a possible inverse association between analgesic use, particularly aspirin, and ovarian cancer risk.<\/jats:p>","DOI":"10.1111\/j.1600-0412.2012.01472.x","type":"journal-article","created":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T10:49:11Z","timestamp":1338461351000},"page":"1094-1102","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Use of analgesic drugs and risk of ovarian cancer: results from a Danish case\u2013control study"],"prefix":"10.1111","volume":"91","author":[{"given":"HENRIETTE B.","family":"AMMUNDSEN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"METTE T.","family":"FABER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALLAN","family":"JENSEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ESTRID","family":"H\u00d8GDALL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAN","family":"BLAAK\u00c6R","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CLAUS","family":"H\u00d8GDALL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUSANNE K.","family":"KJ\u00c6R","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,15]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.12.015"},{"key":"e_1_2_8_3_2","unstructured":"EngholmG FerlayJ ChristensenN GjerstorffML JohannesenTB Klint\u00c5 et al.NORDCAN: Cancer Incidence Mortality Prevalence and Survival in the Nordic Countries. 2011 Version 4.0. 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