{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:24:30Z","timestamp":1790130270899,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,8,15]],"date-time":"2012-08-15T00:00:00Z","timestamp":1344988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To assess the level of compliance with follow\u2010up over time after treatment for preinvasive and Stage Ia1 lesions of the cervix. To compare the average interval between visits with the interval prescribed by protocol and to evaluate the use of this difference as a measure of compliance. <jats:italic>Design.<\/jats:italic> Retrospective observational study. <jats:italic>Setting.<\/jats:italic> London university hospital. <jats:italic>Population.<\/jats:italic> Women who received treatment for preinvasive (CINI\u2010III, AIS) or Stage Ia1 cervical lesions. <jats:italic>Methods.<\/jats:italic> Attendance data were obtained from hospital\u2010based colposcopy and community\u2010based databases. <jats:italic>Main outcome measures.<\/jats:italic> The average interval between the appointments attended by each woman was compared with the planned interval between visits. The time that elapsed since the previous appointment attended was calculated for each visit and correlated with the time since treatment. <jats:italic>Results.<\/jats:italic> 1013 women attended 4128 follow\u2010up visits in the colposcopy clinic and in the community. Twenty\u2010two (2.2%) women never attended any post\u2010treatment appointment and 209 (21.0%) of the 991 women who attended at least once, did so on average more than 12 months later than specified by the follow\u2010up protocol. There was a highly significant correlation between the interval since the previous appointment and the time since treatment (Kendall's tau b = 0.529614, two\u2010sided <jats:italic>p<\/jats:italic> &lt; 0.0001), showing that compliance deteriorates with increasing time since treatment. <jats:italic>Conclusions.<\/jats:italic> Comparing the average interval between attendances with the planned interval prescribed by protocol is a sensitive measure of compliance. Compliance with follow\u2010up deteriorates significantly with time since treatment. This decline in compliance may contribute to the increased risk of invasive disease after treatment.<\/jats:p>","DOI":"10.1111\/j.1600-0412.2012.01477.x","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T01:13:10Z","timestamp":1339031590000},"page":"1103-1108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Long\u2010term compliance with follow\u2010up after treatment for cervical intra\u2010epithelial neoplasia"],"prefix":"10.1111","volume":"91","author":[{"given":"WILLIAM PATRICK","family":"SOUTTER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BRONWEN","family":"MOSS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAREN","family":"PERRYMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIA","family":"KYRGIOU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KATERINA","family":"PAPAKONSTANTINOU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SADAF","family":"GHAEM\u2010MAGHAMI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,15]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16674-9"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21604"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38663.459039.7C"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.12.028"},{"key":"e_1_2_8_6_2","first-page":"223","article-title":"Is default from colposcopy a problem, and if so what can we do? 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