{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:04:01Z","timestamp":1778155441709,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T00:00:00Z","timestamp":1345507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract\u2002<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To compare the effects of a monophasic combined oral contraceptive containing nomegestrol acetate\/17\u03b2\u2010estradiol (NOMAC\/E2) on bone mineral density with a combined oral contraceptive containing levonorgestrel\/ethinylestradiol (LNG\/EE). <jats:italic>Design.<\/jats:italic> Prospective, randomized, open\u2010label, comparative clinical study. <jats:italic>Setting.<\/jats:italic> Gynecology center in Norway. <jats:italic>Population.<\/jats:italic> One hundred and ten women (20\u201335 years old) actively seeking contraception. <jats:italic>Methods.<\/jats:italic> For 26 consecutive 28\u2010day cycles, women received one of the following two treatments: NOMAC\/E2 (2.5 mg\/1.5 mg) in a 24\/4\u2010day regimen (<jats:italic>n<\/jats:italic>= 56); or LNG\/EE (150 \u03bcg\/30 \u03bcg) in a 21\/7\u2010day regimen (<jats:italic>n<\/jats:italic>= 54). <jats:italic>Main outcome measures.<\/jats:italic> Bone mineral density of the lumbar spine, femoral neck, hip and trochanter (measured by dual energy X\u2010ray absorptiometry); associated z\u2010scores of the lumbar spine and femoral neck. <jats:italic>Results.<\/jats:italic> In NOMAC\/E2 users, mean (\u00b1SD) z\u2010score change from baseline for lumbar spine and femoral neck were 0.019 \u00b1 0.242 and \u22120.007 \u00b1 0.228, respectively, vs. 0.121 \u00b1 0.269 and 0.044 \u00b1 0.253 in LNG\/EE users, respectively. Differences between treatment groups were not significant (<jats:italic>p<\/jats:italic>= 0.19 and <jats:italic>p<\/jats:italic>= 0.57, respectively). There were no significant differences between changes in hip and trochanter z\u2010scores between NOMAC\/E2 and LNG\/EE treatments. <jats:italic>Conclusions.<\/jats:italic> After two years, NOMAC\/E2 had no clinically relevant effect on bone mineral density. No significant difference in the effect on bone mineral density between NOMAC\/E2 and LNG\/EE was observed.<\/jats:p>","DOI":"10.1111\/j.1600-0412.2012.01498.x","type":"journal-article","created":{"date-parts":[[2012,7,4]],"date-time":"2012-07-04T23:46:23Z","timestamp":1341445583000},"page":"1279-1285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effects on bone mineral density of a monophasic combined oral contraceptive containing nomegestrol acetate\/17\u03b2\u2010estradiol in comparison to levonorgestrel\/ethinylestradiol"],"prefix":"10.1111","volume":"91","author":[{"given":"TERJE","family":"S\u00d8RDAL","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAUL","family":"GROB","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CAROLE","family":"VERHOEVEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,21]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2006.01.003"},{"issue":"7","key":"e_1_2_9_3_2","first-page":"CD006033","article-title":"Steroidal contraceptives: effect on bone fractures in women","author":"Lopez LM","year":"2011","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_9_4_2","first-page":"1023","article-title":"Oral contraceptive use and bone mineral density in premenopausal women: cross\u2010sectional, population\u2010based data from the Canadian Multicentre Osteoporosis Study","volume":"165","author":"Prior JC","year":"2001","journal-title":"CMAJ."},{"key":"e_1_2_9_5_2","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1001\/archinte.1991.00400100053009","article-title":"Oral contraceptive use may protect against low bone mass. 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