{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:28:33Z","timestamp":1793986113785,"version":"4.8.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T00:00:00Z","timestamp":1350432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To study associations of placental growth factor (PlGF) and soluble fms\u2010like tyrosine kinase 1 (sFlt\u20101) in maternal circulation with the risk of preeclampsia with and without fetal growth restriction. <jats:italic>Design.<\/jats:italic> Nested case\u2010control study. <jats:italic>Setting.<\/jats:italic> A cohort of 29 948 pregnant women in Norway. <jats:italic>Sample.<\/jats:italic> Cases were identified through linkage to the Medical Birth Registry of Norway. We selected 69 preterm and 36 term preeclampsia cases with delivery of a small\u2010for\u2010gestational\u2010age (SGA) infant, 83 preterm and 154 term preeclampsia cases without SGA delivery, and 384 normotensive controls. <jats:italic>Methods.<\/jats:italic> We measured PlGF and sFlt\u20101 in maternal serum samples from each trimester. <jats:italic>Main outcome measures.<\/jats:italic> Odds ratios of preeclampsia subtypes by tertile categories of PlGF and sFlt\u20101. <jats:italic>Results.<\/jats:italic> Low (lowest third) PlGF and sFlt\u20101 levels in the first trimester, and low (lowest third) increase in PlGF and strong (highest third) increase in sFlt\u20101 from first to second trimester were associated with increased risk of preterm preeclampsia, both with and without SGA offspring. For term preeclampsia with SGA offspring, the associations were similar to the findings for preterm preeclampsia. For term preeclampsia without SGA offspring, low increase in PlGF from first to second trimester and high sFlt\u20101 in the third trimester were associated with increased risk. <jats:italic>Conclusions.<\/jats:italic> Low PlGF and high sFlt\u20101 levels in maternal circulation are associated with subsequent development of preeclampsia, regardless of whether fetal growth is affected or not. For term preeclampsia without fetal growth restriction, the imbalance in angiogenic factors seems to appear later in pregnancy than for preterm preeclampsia.<\/jats:p>","DOI":"10.1111\/j.1600-0412.2012.01516.x","type":"journal-article","created":{"date-parts":[[2012,8,10]],"date-time":"2012-08-10T12:35:25Z","timestamp":1344602125000},"page":"1388-1394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Angiogenic factors in maternal circulation and preeclampsia with or without fetal growth restriction"],"prefix":"10.1111","volume":"91","author":[{"given":"LARS J.","family":"VATTEN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BJ\u00d8RN 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