{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:41:38Z","timestamp":1790077298737,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T00:00:00Z","timestamp":1361491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objectives.<\/jats:italic> To study the prevalence of high\u2010grade cervical intraepithelial neoplasia (CIN 2\u20133) during pregnancy and compare the rates of persistence, progression and regression of CIN 2\u20133 by colposcopically guided biopsy during pregnancy with respect to the postpartum period. Also to assess biopsy results during pregnancy and postpartum in relation to histopathology after treatment of lesions. <jats:italic>Population.<\/jats:italic> Pregnant women with a histological diagnosis of CIN 2\u20133 confirmed by colposcopically guided biopsy during pregnancy. <jats:italic>Methods.<\/jats:italic> Between 1989 and 2008, 11 700 pregnant women had cytologic and simultaneous colposcopic examinations during pregnancy. A colposcopically guided biopsy was performed when colposcopically suspicious high\u2010grade lesions were detected, regardless of cytological results. Women with a histopathological diagnosis of CIN 2\u20133 during pregnancy were re\u2010evaluated by colposcopically guided biopsy and treated during the postpartum period. <jats:italic>Results<\/jats:italic>. CIN 2\u20133 was diagnosed in 56 of 11 700 (0.48%) pregnant women by biopsy. Thirty women complying with the protocol were assessed postpartum by histopathological studies, of whom 70% exhibited persistence, 13.3% progression and 16.7% regression of CIN 2\u20133. Twenty\u2010nine were diagnosed by conization and one by colposcopically guided biopsy during the postpartum period, which revealed invasive cervical carcinoma. <jats:italic>Conclusions<\/jats:italic>. Due to the high rates of CIN 2\u20133 persistence during the postpartum period, we suggest that all patients in whom CIN 2\u20133 was diagnosed during pregnancy are biopsied and treated if necessary during the postpartum period, with at least a two\u2010year follow\u2010up control to prevent lesion recurrence.<\/jats:p>","DOI":"10.1111\/j.1600-0412.2012.01521.x","type":"journal-article","created":{"date-parts":[[2012,8,10]],"date-time":"2012-08-10T12:32:20Z","timestamp":1344601940000},"page":"293-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["High\u2010grade cervical neoplasia during pregnancy: diagnosis, management and postpartum findings"],"prefix":"10.1111","volume":"92","author":[{"given":"ENRIQUE F.","family":"COPPOLILLO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HILDA MALAMUD","family":"DE RUDA 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