{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T04:32:24Z","timestamp":1781065944755,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,3,23]],"date-time":"2004-03-23T00:00:00Z","timestamp":1080000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Ophthalmologica Scandinavica"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> To evaluate the effects of early systemic administration of betamethasone or cyclosporin A (CsA) on inflammatory cytokine expression and corneal damage after alkali injury.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Sixty\u2010five Wistar rat corneas injured with 1N\u2003NaOH were divided into three groups: untreated, betamethasone\u2010treated and CsA\u2010treated. Both agents were administered systemically and daily during the first 7\u2003days after injury. Interleukin (IL)\u20101\u03b1, \u20106 and \u20108 concentrations in the injured corneas were measured with ELISA at 2, 4 and 7\u2003days after injury. Corneal damage was evaluated by scoring clinical findings.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In untreated injured corneas, IL\u20101\u03b1, \u20106 and \u20108 were markedly elevated during the 7\u2010day period following injury. Both betamethasone and CsA significantly suppressed IL\u20101\u03b1 and IL\u20108 at day 4. Only betamethasone significantly suppressed IL\u20106 at days 4 and 7. Both agents significantly reduced corneal opacity at day 4.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Early systemic administration of betamethasone or CsA after alkali injury may be of benefit by suppressing inflammatory cytokine expression in the cornea.<\/jats:p>","DOI":"10.1111\/j.1600-0420.2004.00229.x","type":"journal-article","created":{"date-parts":[[2004,12,19]],"date-time":"2004-12-19T05:35:57Z","timestamp":1103434557000},"page":"195-199","source":"Crossref","is-referenced-by-count":28,"title":["Efficacy of early systemic betamethasone or cyclosporin A after corneal alkali injury via inflammatory cytokine reduction"],"prefix":"10.1111","volume":"82","author":[{"given":"Seika","family":"Den","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Sotozono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunehiko","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,3,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00289-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(70)90494-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.3.318"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1989.tb04402.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1987.tb07036.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004170050118"},{"key":"e_1_2_6_8_1","first-page":"330","article-title":"Differences in interleukin\u20106 gene expression between cultured human corneal epithelial cells and keratocytes","volume":"36","author":"Cubitt CL","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_9_1","first-page":"977","article-title":"IL\u20108 gene expression in cultures of human corneal epithelial cells and keratocytes","volume":"139","author":"Cubitt CL","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_10_1","first-page":"664","article-title":"The effect of betamethasone and cyclosporin A on retinal cytokine expression in the early stages after corneal alkali injury. 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