{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:49:57Z","timestamp":1762541397691},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,3,23]],"date-time":"2004-03-23T00:00:00Z","timestamp":1080000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Ophthalmologica Scandinavica"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> To report a case of delayed fungal endophthalmitis by <jats:italic>Paecilomyces variotii<\/jats:italic> following uncomplicated cataract surgery. To our knowledge this is the first reported case of postoperative endophthalmitis by this species.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We report the longterm clinical follow\u2010up of an 83\u2010year\u2010old female who underwent uncomplicated sutureless, small\u2010incision cataract surgery. She developed recurring uveitis 4\u2003months after surgery. Vitreous tap and finally complete vitrectomy with removal of the capsular bag including the intraocular lens were performed. Fungi were studied by histopathology and culture.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> At histopathological examination, the fungi were found to be closely related with the capsular bag. A few mononuclear inflammatory cells were encountered. At culture, <jats:italic>Paecilomyces variotii<\/jats:italic>, a common ubiquitous non\u2010pathogenic saprophyte, was identified. Despite systemic, intravitreal and topical antifungal therapy after vitrectomy the uveitis recurred several times, but no fungal organisms were isolated from the repeat intraocular specimen. At 18\u2003months postoperatively the subject's visual acuity was finger counting at 2\u2003metres. At the time of surgery the operating room air\u2010conditioning system was undergoing repairs. Cases of fungal endophthalmitis after contamination from air\u2010conditioning ventilation systems have been reported before, but none of the cases reported have been caused by <jats:italic>P.\u2003variotii.<\/jats:italic><\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>  <jats:italic>P.\u2003variotii<\/jats:italic>, a non\u2010pathogenic environmental saprophyte, may be disastrous if introduced into the eye. International recommendations on the environmental control of the operating room air\u2010conditioning ventilation system should be strictly followed. No intraoperative surgery should be undertaken while the air\u2010conditioning system is undergoing repairs or service.<\/jats:p>","DOI":"10.1111\/j.1600-0420.2004.00235.x","type":"journal-article","created":{"date-parts":[[2004,12,19]],"date-time":"2004-12-19T05:35:57Z","timestamp":1103434557000},"page":"232-235","source":"Crossref","is-referenced-by-count":27,"title":["Fungal endophthalmitis caused by <i>Paecilomyces variotii<\/i> following cataract surgery: a presumed operating room air\u2010conditioning system contamination"],"prefix":"10.1111","volume":"82","author":[{"given":"Ahti","family":"Tarkkanen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virpi","family":"Raivio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veli\u2010Jukka","family":"Anttila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petri","family":"Tommila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reijo","family":"Ralli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauri","family":"Merenmies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilkka","family":"Immonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,23]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/02681219080000031"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2002.1217"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1035411"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.2.222"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000309108"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080080045025"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(75)90730-8"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(98)00036-8"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1999.23"},{"key":"e_1_2_4_11_1","first-page":"253","article-title":"Endooftalmitis pro Penicillium lilacinum","volume":"48","author":"Malbran E","year":"1973","journal-title":"Arch Oftalmol Buenos Aires"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)01180-1"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(77)90206-9"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1980.01020031015002"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90395-0"},{"key":"e_1_2_4_16_1","first-page":"916","article-title":"Exogenous endophthalmitis caused by amphotericin B\u2010resistant Paecilomyces lilacinus: treatment options and visual outcomes","volume":"119","author":"Scott IU","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1992.01080190019003"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.5.1023"}],"container-title":["Acta Ophthalmologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0420.2004.00235.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0420.2004.00235.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T08:12:45Z","timestamp":1697184765000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0420.2004.00235.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,23]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1111\/j.1600-0420.2004.00235.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0420.2004.00235.x","archive":["Portico"],"relation":{},"ISSN":["1395-3907","1600-0420"],"issn-type":[{"value":"1395-3907","type":"print"},{"value":"1600-0420","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,23]]}}}