{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:13:30Z","timestamp":1757704410987},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,9,28]],"date-time":"2004-09-28T00:00:00Z","timestamp":1096329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Ophthalmologica Scandinavica"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold>  <jats:bold>To establish whether the presentation of choroidal and ciliary body melanomas and patient survival have changed during the period 1955\u20132000.<\/jats:bold> <\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold>  <jats:bold>The study included 209 unselected patients (97 men, 112 women) from \u00c5rhus County during the period 1955\u20132000. The median age at treatment was 64\u2003years (range 26\u201388\u2003years). The disease course from first symptom through clinical and histopathological findings to death was described in a historical follow\u2010up design. Time trends were evaluated.<\/jats:bold> <\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>  <jats:bold>Treatment modality changed over time from enucleation to an almost equal distribution between enucleation and radiation brachytherapy. The age at treatment, or, alternatively, at diagnosis, increased significantly (p\u2003<jats:italic>=<\/jats:italic>\u20030.04). No significant time trend was seen for largest basal tumour diameter (p\u2003<jats:italic>=<\/jats:italic>\u20030.08) or tumour height (p\u2003<jats:italic>=<\/jats:italic>\u20030.27). The clinical and histopathological findings did not show any consistent time trends. No significant time trend was found for melanoma\u2010specific survival (p\u2003<jats:italic>=<\/jats:italic>\u20030.96) or overall survival (p\u2003<jats:italic>=<\/jats:italic>\u20030.33).<\/jats:bold> <\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>  <jats:bold>No consistent time trends were seen in clinical and histopathological tumour presentation and survival in patients with choroidal or ciliary body melanomas. The increase in age at treatment was in line with an increase in life expectancy in Denmark.<\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.1600-0420.2004.00329.x","type":"journal-article","created":{"date-parts":[[2004,9,28]],"date-time":"2004-09-28T15:41:43Z","timestamp":1096386103000},"page":"509-516","source":"Crossref","is-referenced-by-count":5,"title":["Have choroidal and ciliary body melanomas changed during the period 1955\u20132000?"],"prefix":"10.1111","volume":"82","author":[{"given":"Peter","family":"Isager","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Ehlers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Overgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1998.202"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004170050279"},{"key":"e_1_2_7_4_1","volume-title":"The Reactions of Fixatives with Tissues and Cells: Methods of Research. 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