{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:09:52Z","timestamp":1768720192114,"version":"3.49.0"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,9,28]],"date-time":"2004-09-28T00:00:00Z","timestamp":1096329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Ophthalmologica Scandinavica"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold>  <jats:bold>To evaluate prognostic factors for the survival of patients treated by enucleation for choroidal and ciliary body melanomas.<\/jats:bold> <\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>  <jats:bold>The study included 293 consecutive patients (147 men and 146 women) treated by enucleation for a choroidal or ciliary body melanoma during the period 1955\u20132000. The median age at treatment was 61\u2003years (range 26\u201388\u2003years). Clinical and histopathological findings, vital status at October 1st, 2002, and cause of death were registered. Prognostic factors for survival were evaluated by univariate and multivariate Cox proportional hazards analysis and by Kaplan\u2013Meier survival analysis.<\/jats:bold> <\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>  <jats:bold>Follow\u2010up was complete. The median follow\u2010up time was 6.2\u2003years (range 21\u2003days to 43.4\u2003years) and the median potential follow\u2010up time was 25.7\u2003years (range 1.9\u201347.7\u2003years). In multivariate Cox proportional hazards analysis an increased risk of melanoma\u2010related death was found for largest basal diameter (<jats:italic>n<\/jats:italic>\u2003=\u2003264, p\u2003&lt;\u20030.001, mortality rate ratio (RR)\u2003=\u20031.09 for continuous parameter in mm), anterior tumour margin at the iris\/ciliary body versus choroid (p &lt;\u20030.001, RR\u2003=\u20032.22), and non\u2010spindle cell type versus spindle cell (p =\u20030.047, RR\u2003=\u20031.45). An increased risk of death from all causes was found for men versus women (<jats:italic>n<\/jats:italic>\u2003=\u2003266, p\u2003=\u20030.02, RR\u2003=\u20031.41), high age (p &lt;\u20030.001, RR\u2003=\u20031.41 for continuous parameter in 10\u2010year age groups), largest basal diameter (p &lt;\u20030.001, RR\u2003=\u20031.07), anterior tumour margin at the iris\/ciliary body (p =\u20030.02, RR\u2003=\u20031.52), and non\u2010spindle cell type (p =\u20030.04, RR\u2003=\u20031.34).<\/jats:bold> <\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>  <jats:bold>The risk of melanoma\u2010related death after enucleation for a choroidal or ciliary body melanoma was high for tumours with large basal diameter, of non\u2010spindle cell type and anterior location. Additional risk factors for death from all causes were male sex and high age.<\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.1600-0420.2004.00330.x","type":"journal-article","created":{"date-parts":[[2004,9,28]],"date-time":"2004-09-28T15:41:43Z","timestamp":1096386103000},"page":"517-525","source":"Crossref","is-referenced-by-count":49,"title":["Prognostic factors for survival after enucleation for choroidal and ciliary body melanomas"],"prefix":"10.1111","volume":"82","author":[{"given":"Peter","family":"Isager","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Ehlers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Overgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1980.01020040827006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901001)66:7<1596::AID-CNCR2820660726>3.0.CO;2-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(85)34068-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.5962\/bhl.title.5905"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)72211-1"},{"key":"e_1_2_6_7_1","first-page":"131","article-title":"Malignant melanotic tumours of the eye: a study of histologic types in 111 cases","volume":"36","author":"Callender GR","year":"1931","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)72110-5"},{"key":"e_1_2_6_9_1","first-page":"293","article-title":"Cytomorphometry of uveal melanoma. 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