{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:19:51Z","timestamp":1773281991234,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,12,3]],"date-time":"2004-12-03T00:00:00Z","timestamp":1102032000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Ophthalmologica Scandinavica"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold>  <jats:bold>To evaluate the effects of dorzolamide\/timolol fixed combination (D\/T) compared to latanoprost on intraocular pressure (IOP) and pulsatile ocular blood flow (POBF) in primary open\u2010angle glaucoma (POAG) patients.<\/jats:bold> <\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>  <jats:bold>Thirty patients with POAG were randomized in an open\u2010label, cross\u2010over study. Intraocular pressure reduction was achieved by 4\u2003weeks medical therapy with D\/T twice daily or latanoprost 0.005% dosed once in the evening. During a 4\u2010week run\u2013in and a 4\u2010week wash\u2010out period between study arms, patients ceased use of all other glaucoma medications and used timolol maleate 0.5% twice daily. Primary efficacy variables were IOP and POBF.<\/jats:bold> <\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>  <jats:bold>There was no difference in baseline IOP and POBF parameters between the two study arms. Both D\/T and latanoprost statistically significantly reduced IOP by 4.6\u2003mmHg (p\u2003&lt;\u20030.0001) and 3.75\u2003mmHg (p\u2003&lt;\u20030.0001) and increased POBF by 2.048\u2003\u00b5l\/second (p\u2003=\u20030.0030) and 2.147\u2003\u00b5l\/second (p\u2003=\u20030.0009), respectively. Repeated measures <jats:sc>anova<\/jats:sc> detected significant changes in POBF with treatment (p\u2003=\u20030.0361). Dorzolamide\/timolol fixed combination statistically significantly increased pulse volume by 0.767\u2003\u00b5l (p\u2003=\u20030.0087), while latanoprost therapy had no significant effect (p\u2003=\u20030.2407).<\/jats:bold> <\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>  <jats:bold>Both drugs had similar effects in terms of IOP reduction. Dorzolamide\/timolol significantly increased pulse volume while latanoprost had no effect. Further studies are necessary to establish whether the enhancement of choroidal blood flow can prevent glaucoma progression.<\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.1600-0420.2004.00358.x","type":"journal-article","created":{"date-parts":[[2004,12,19]],"date-time":"2004-12-19T05:30:29Z","timestamp":1103434229000},"page":"730-737","source":"Crossref","is-referenced-by-count":33,"title":["A comparison of the effects of dorzolamide\/timolol fixed combination versus latanoprost on intraocular pressure and pulsatile ocular blood flow in primary open\u2010angle glaucoma 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