{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:04:38Z","timestamp":1772816678445,"version":"3.50.1"},"reference-count":72,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,3,2]],"date-time":"2005-03-02T00:00:00Z","timestamp":1109721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Ophthalmologica Scandinavica"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold>  <jats:bold>Numerous studies have confirmed the enhancement of ocular circulation by carbonic anhydrase inhibitors (CAIs). Topical CAI treatment with dorzolamide averts the significant pericentral visual function loss accompanying retinal and choroidal vasoconstriction during acute hyperventilation\u2010induced hypocapnia. This study was designed to discern whether dorzolamide might similarly enhance macular function in patients with age\u2010related maculopathy (ARM).<\/jats:bold> <\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>  <jats:bold>In a masked, placebo\u2010controlled study, 40 patients with ARM and acuity &gt;\u200320\/50 were randomized to receive either dorzolamide or placebo for 12\u2003weeks, thrice daily. After pre\u2010study perimetric training, pericentral function (mean sensitivity) was quantified using Humphrey 10\u20132 short\u2010wavelength automated perimetry (SWAP), before and after 12\u2003weeks of topical therapy.<\/jats:bold> <\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>  <jats:bold>Dorzolamide\u2010treated eyes demonstrated a significant increase in mean sensitivity of +\u20031.55\u2003dB (p\u2003<jats:italic>=<\/jats:italic>\u20030.04); placebo\u2010treated eyes showed no significant change (+\u20030.58\u2003dB; p\u2003=\u20030.10). Given the non\u2010significant increase of mean sensitivity in the placebo\u2010treated group, fewer than 100 subjects per group would be required to afford &gt;\u200370% power to yield a significant direct comparative difference between treatment and placebo in a prospective, randomized study of equally short duration.<\/jats:bold> <\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>  <jats:bold>This study demonstrated a significant increase in short\u2010wavelength sensitivity in ARM with dorzolamide and the lack thereof with placebo. These encouraging pilot study data suggest a potential role for topical CAIs in ARM patients, and establish objective parameters for prospective studies to further evaluate the effects of dorzolamide in ARM.<\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.1600-0420.2005.00406.x","type":"journal-article","created":{"date-parts":[[2005,3,30]],"date-time":"2005-03-30T10:25:41Z","timestamp":1112178341000},"page":"154-160","source":"Crossref","is-referenced-by-count":8,"title":["Topical dorzolamide increases pericentral visual function in age\u2010related maculopathy: pilot study findings with short\u2010wavelength automated perimetry"],"prefix":"10.1111","volume":"83","author":[{"given":"Andreas","family":"Remky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Arend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Eric","family":"Sponsel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,3,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/47.9.941"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1972.tb05182.x"},{"key":"e_1_2_5_4_1","first-page":"424","article-title":"Ocular effects of changes in oxygen and carbon dioxide tension","volume":"66","author":"Anderson B","year":"1968","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.10.1417"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2003.00122.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000068201"},{"key":"e_1_2_5_8_1","first-page":"122","article-title":"Aspects of physiological and pharmacological regulation of uveal blood flow","volume":"67","author":"Bill A","year":"1962","journal-title":"Acta Soc Med Upsalien"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-4327(88)90022-3"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.12.1411"},{"key":"e_1_2_5_11_1","first-page":"334","article-title":"Functional loss in age\u2010related Bruch's membrane change with choroidal perfusion defect","volume":"33","author":"Chen JC","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00061-6"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.2.209"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-1856-9_23"},{"key":"e_1_2_5_15_1","first-page":"3091","article-title":"Visual function and the subsequent development of exudative age\u2010related macular degeneration","volume":"33","author":"Eisner A","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70906-7"},{"key":"e_1_2_5_17_1","first-page":"70","article-title":"Choroidal blood flow. 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