{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T11:19:48Z","timestamp":1753183188134},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Ophthalmologica Scandinavica"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold>  <jats:bold>To assess short\u2010term changes in macular function after transpupillary thermotherapy (TTT) in patients with occult subfoveal choroidal neovascularization (CNV) secondary to age\u2010related macular degeneration (AMD), using focal electroretinography (FERG).<\/jats:bold> <\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>  <jats:bold>Twenty\u2010five patients with occult subfoveal CNV due to AMD were treated with TTT delivered using an infrared (810\u2003nm) diode laser (spot size 3.0\u2003mm, laser power 400\u2013600\u2003mW, duration 60\u2003seconds). All patients were clinically evaluated before, 1 and 6\u2003weeks after treatment. Snellen visual acuity (VA) was measured at each visit. Fluorescein angiography (FA) was performed at baseline and 6\u2003weeks after TTT. Focal ERGs were recorded in all patients immediately before and 1\u2003week after TTT in response to an 18\u2010degree diameter, 41\u2003Hz flickering spot (630\u2003nm) centred on the fovea, presented on a steady background in Maxwellian view. A subgroup of 12 patients was also re\u2010tested by FERG at 6\u2010weeks post\u2010TTT.<\/jats:bold> <\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>  <jats:bold>No significant changes in mean FERG amplitude and phase were observed across the different recording sessions before and after TTT. One week after TTT, four patients had significant (&gt;2\u2003SD from baseline variability) increases in FERG amplitude and\/or phase advances, one had a decrease in amplitude and four had phase delays, compared to baseline. The remaining 15 patients had stable FERGs. Six weeks after TTT, four patients had significant increases in FERG amplitude and\/or phase advances, four had decreases in amplitude and\/or phase delays, and four had stable FERGs, compared to baseline. Improvement in FERG parameters after TTT was always associated with an improvement in VA and a decrease in exudation. Patients with post\u2010TTT FERG deterioration had stable or deteriorated clinical pictures. At either 1 or 6\u2003weeks post\u2010TTT, the FERG amplitude increase was inversely correlated (p\u2003<jats:italic>&lt;<\/jats:italic>\u20030.05) with the baseline FERG amplitude and VA.<\/jats:bold> <\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>  <jats:bold>Three major conclusions can be drawn: in a short\u2010term follow\u2010up, TTT was not found to be associated with significant changes in macular function; FERG improvement was associated with VA improvement, and the increase in FERG amplitude was greatest in patients with the worst baseline acuity.<\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.1600-0420.2005.00529.x","type":"journal-article","created":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T09:58:21Z","timestamp":1125568701000},"page":"27-35","source":"Crossref","is-referenced-by-count":4,"title":["Retinal function following transpupillary thermotherapy for occult choroidal neovascularization in age\u2010related macular degeneration: a short\u2010term study by focal electroretinography"],"prefix":"10.1111","volume":"84","author":[{"given":"Enza","family":"Pirozzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Manganelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Piccardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Minnella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonello","family":"Fadda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Ziccardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Coccimiglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetto","family":"Falsini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1076\/soph.16.2.81.4215"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2003.00041.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00154734"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2188360"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01694-X"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00154487"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00154401"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00223-X"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1965.sp007678"},{"key":"e_1_2_5_11_1","first-page":"3337","article-title":"Transpupillary thermotherapy for subfoveal choroidal neovascularization: effect on ocular perfusion","volume":"42","author":"Ciulla T","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_12_1","first-page":"2976","article-title":"Heat shock protein hyperexpression on chorioretinal layers after transpupillary thermotherapy","volume":"42","author":"Desmettre T","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02534106"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-2607(89)90180-6"},{"issue":"6","key":"e_1_2_5_15_1","first-page":"1498","article-title":"Retinal sensitivity to flicker modulation: reduced by early age\u2010related maculopathy","volume":"41","author":"Falsini B","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0716"},{"key":"e_1_2_5_17_1","first-page":"4282","article-title":"Postreceptoral contribution to macular dysfunction in retinitis pigmentosa","volume":"35","author":"Falsini B","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713689609008904"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004170050218"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1395-3907.2004.0189a.x"},{"key":"e_1_2_5_21_1","first-page":"875","volume-title":"Retina.","author":"Johnson RN","year":"2001"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01034-5"},{"key":"e_1_2_5_23_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3928\/1542-8877-20000901-03","article-title":"Transpupillary thermotherapy for age\u2010related macular degeneration: long\u2010pulse photocoagulation, apoptosis and heat shock proteins","volume":"31","author":"Mainster MA","year":"2000","journal-title":"Ophthalmic Surg Lasers"},{"issue":"11","key":"e_1_2_5_24_1","first-page":"3136","article-title":"Mid\u2010frequency loss of foveal flicker sensitivity in early stages age\u2010related maculopathy","volume":"33","author":"Mayer MJ","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-1329"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.2.173"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656738709140422"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820539809056051"},{"issue":"4","key":"e_1_2_5_29_1","first-page":"S320","article-title":"Transpupillary thermotherapy for subfoveal choroidal neovascularization in age\u2010related macular degeneration. [Abstract no. 1689.]","volume":"41","author":"Petrone S","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_30_1","first-page":"323","article-title":"Steady\u2010state analysis of the focal ERG to pattern and flicker relationships between ERG components and retinal pathology","volume":"4","author":"Porciatti V","year":"1989","journal-title":"Clin Vis Sci"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90400-1"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.79.6.558"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2003.t01-1-00025.x"},{"key":"e_1_2_5_34_1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1379\/1466-1268(1998)003<0228:HSPROS>2.3.CO;2","article-title":"Heat shock proteins: regulators of stress response and apoptosis","volume":"3","author":"Samali A","year":"1988","journal-title":"Cell Stress Chaperones"},{"key":"e_1_2_5_35_1","first-page":"3477","article-title":"Foveal cone ERGs in fellow eyes of patients with unilateral neovascular age\u2010related macular degeneration","volume":"34","author":"Sandberg MA","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1017562532731"},{"key":"e_1_2_5_37_1","first-page":"1592","article-title":"Evaluation of an iris colour classification system. The Eye Disorders Case\u2010Control Study Group","volume":"31","author":"Seddon JM","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"e_1_2_5_38_1","first-page":"2638","article-title":"Sites of cone system sensitivity loss in retinitis pigmentosa","volume":"34","author":"Seiple WH","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_39_1","first-page":"1123","article-title":"Evaluating macular function using the focal ERG. 1","volume":"27","author":"Seiple WH","year":"1986","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-199906000-00008"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30451-X"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1997.01100150347006"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200306000-00008"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00879-5"}],"container-title":["Acta Ophthalmologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0420.2005.00529.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0420.2005.00529.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T11:09:41Z","timestamp":1697454581000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0420.2005.00529.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1111\/j.1600-0420.2005.00529.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0420.2005.00529.x","archive":["Portico"],"relation":{},"ISSN":["1395-3907","1600-0420"],"issn-type":[{"value":"1395-3907","type":"print"},{"value":"1600-0420","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}