{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:25:00Z","timestamp":1789575900457,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,10,31]],"date-time":"2005-10-31T00:00:00Z","timestamp":1130716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Ophthalmologica Scandinavica"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold>  <jats:bold>To evaluate the joint effects of donor age and cause of death on the endothelial cell density of fresh human corneas.<\/jats:bold> <\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>  <jats:bold>The corneal endothelial cell density of 946 eyes from 946 donors was analysed. The donors were divided into three age groups: group 1 comprised those aged 50\u2003years and less; group 2 those aged 51\u201375\u2003years, and group 3 those aged over 75\u2003years. They were also grouped according to the cause of death: group A included those who had died of cancer; group B those who had died of acute myocardial infarction, pulmonary embolism or intracerebral haemorrhage, and group C those who had died as a result of other diseases.<\/jats:bold> <\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>  <jats:bold>There was a statistically significant negative correlation between donor age and mean corneal endothelial cell density, which was 2868\u2003\u00b1\u2003309 cells\/mm<jats:sup>2<\/jats:sup> in group 1, 2716\u2003\u00b1\u2003335 cells\/mm<jats:sup>2<\/jats:sup> in group 2, and 2670\u2003\u00b1\u2003368 cells\/mm<jats:sup>2<\/jats:sup> in group 3. Among the various causes of death, the mean endothelial cell density was 2677\u2003\u00b1\u2003343 cells\/mm<jats:sup>2<\/jats:sup> in group A, 2741\u2003\u00b1\u2003367 cells\/mm<jats:sup>2<\/jats:sup> in group B, and 2713\u2003\u00b1\u2003337 cells\/mm<jats:sup>2<\/jats:sup> in group C. The endothelial cell density was significantly lower in group A than in group B (p\u2003=\u20030.02). When the donors in the oldest age group (group 3) were analysed according to the various causes of death, the difference between group A (2603\u2003\u00b1\u2003342 cells\/mm<jats:sup>2<\/jats:sup>) and group B (2729\u2003\u00b1\u2003338 cells\/mm<jats:sup>2<\/jats:sup>) was even more significant (p\u2003=\u20030.0067).<\/jats:bold> <\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>  <jats:bold>Longlasting, severe diseases like cancer, leading to cachexia and catabolism, reduce the number of endothelial cells to a greater degree than diseases that cause a more rapid death. This negative effect of cancer on endothelial cell density is aggravated by the general decline in endothelial cell density with advancing age.<\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.1600-0420.2005.00570.x","type":"journal-article","created":{"date-parts":[[2005,10,31]],"date-time":"2005-10-31T16:36:55Z","timestamp":1130776615000},"page":"746-750","source":"Crossref","is-referenced-by-count":25,"title":["The influence of donor age and cause of death on corneal endothelial cell density"],"prefix":"10.1111","volume":"83","author":[{"given":"J\u00f8rgen","family":"Krohn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"H\u00f8vding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"16","article-title":"Factors influencing the suitability of organ\u2010cultured corneas for transplantation","volume":"38","author":"Armitage WJ","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1990.tb04783.x"},{"key":"e_1_2_5_4_1","first-page":"333","article-title":"A comparative study of human corneal keratocyte and endothelial cell density during ageing","volume":"16","author":"M\u00f8ller\u2010Pedersen T","year":"1997","journal-title":"Cornea"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090010084031"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00086-0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30094-3"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(83)34417-1"},{"key":"e_1_2_5_9_1","first-page":"3553","article-title":"The influence of cause of death and age on human corneal metabolism","volume":"35","author":"Redbrake C","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003470050161"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1035404"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000027431"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(84)90120-X"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700145"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199412150-00013"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1982.tb08373.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199511000-00003"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713688509017661"}],"container-title":["Acta Ophthalmologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0420.2005.00570.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0420.2005.00570.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:29:40Z","timestamp":1696984180000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0420.2005.00570.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,28]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1111\/j.1600-0420.2005.00570.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0420.2005.00570.x","archive":["Portico"],"relation":{},"ISSN":["1395-3907","1600-0420"],"issn-type":[{"value":"1395-3907","type":"print"},{"value":"1600-0420","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,28]]}}}