{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:36:16Z","timestamp":1790789776319,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,4,7]],"date-time":"2006-04-07T00:00:00Z","timestamp":1144368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Ophthalmologica Scandinavica"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold>  <jats:bold>Age\u2010related macular degeneration (AMD) is the most frequent cause of severe visual impairment in western countries, but its aetiology remains unclear. A growing body of evidence suggests that inflammation contributes to the pathogenesis of AMD, similarly to that shown for atherosclerosis. In view of a number of shared risk factors between the two entities and the hypothesized link between <jats:italic>Chlamydia pneumoniae<\/jats:italic> infection and atherosclerosis, we investigated whether <jats:italic>C.\u2003pneumoniae<\/jats:italic> might be involved in exudative AMD.<\/jats:bold> <\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>  <jats:bold>To examine whether <jats:italic>C.\u2003pneumoniae<\/jats:italic> contributes to the development of subretinal neovascular (SRNV) membranes in AMD, 13 consecutive SRNV membranes surgically excised from patients with exudative AMD were collected and assayed for the presence of <jats:italic>C.\u2003pneumoniae<\/jats:italic> or other bacterial pathogens by means of polymerase chain reaction (PCR).<\/jats:bold> <\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>  <jats:bold>The age of patients ranged from 68 to 85\u2003years (median 73.5\u2003years). In all 13 SRNV membranes, no DNA of either <jats:italic>C.\u2003pneumoniae<\/jats:italic> or other pathogens was found by PCR.<\/jats:bold> <\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>  <jats:bold>These findings indicate that <jats:italic>C.\u2003pneumoniae<\/jats:italic> is not associated with the development of SRNV membranes in exudative AMD.<\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.1600-0420.2005.00591.x","type":"journal-article","created":{"date-parts":[[2006,4,23]],"date-time":"2006-04-23T16:15:45Z","timestamp":1145808945000},"page":"333-337","source":"Crossref","is-referenced-by-count":13,"title":["<i>Chlamydia pneumoniae<\/i> is not detectable in subretinal neovascular membranes in the exudative stage of age\u2010related macular degeneration"],"prefix":"10.1111","volume":"84","author":[{"given":"Werner","family":"Kessler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian A.","family":"Jantos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Dreier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima","family":"Pavlovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.12.1540"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.5.2744-2747.2000"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.2.585"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.9.996"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(89)90271-1"},{"key":"e_1_2_5_7_1","first-page":"265","article-title":"Accumulation of cholesterol with age in human Bruch's membrane","volume":"42","author":"Curcio CA","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.9.4642"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119681"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700161"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365549409008610"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1994.02170070065013"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000034789.82859.A4"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1128\/jcm.32.4.903-905.1994","article-title":"Diagnostic utility of PCR\u2010enzyme immunoassay, culture and serology for detection of Chlamydia pneumoniae in symptomatic and asymptomatic patients","volume":"32","author":"Gaydos CA","year":"1994","journal-title":"J Clin Microbiol"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.12.2930"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(93)31466-1"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501536102"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)00975-8"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.5.523"},{"key":"e_1_2_5_20_1","unstructured":"KalayogluMV BulaD ArroyoJ GragoudasES&MillerJW(2003b): Detection ofChlamydia pneumoniaein choroidal neovascular membranes isolated from patients with age\u2010related macular degeneration. 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