{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:55:46Z","timestamp":1771048546030,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,2,14]],"date-time":"2006-02-14T00:00:00Z","timestamp":1139875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Ophthalmologica Scandinavica"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold>  <jats:bold>The aim of this study was to clarify whether the clinical, laboratory and genetic aspects of sickle cell disease (SCD) influence the occurrence of vessel alterations in the conjunctiva and retina.<\/jats:bold> <\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>  <jats:bold>A total of 102 SCD patients underwent biomicroscopical and retinal examination, in addition to evaluations of haemoglobin (Hb) and haematocrit (Ht) levels, fetal haemoglobin (HbF) estimations, serum creatinine and albuminuria levels, glomerular filtration rate (GFR) values, phenotypes, \u03b2\u2010globin gene haplotypes and \u03b1\u2010thalassaemia. The relationship between ocular vessel alterations and clinical, laboratory and genetic features were evaluated using chi\u2010squared or Fisher tests and logistic regression analysis. In 13 patients on enalapril treatment, a second ophthalmological evaluation was performed after a 12\u2010month period to evaluate the longitudinal effect of the drug on ocular vessels.<\/jats:bold> <\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>  <jats:bold>Conjunctival vessel alteration (CVA) was not influenced by age, gender, HbF estimation, serum creatinine and albuminuria levels, GFR values, \u03b2\u2010globin gene haplotypes or \u03b1\u2010thalassaemia. However, increased frequencies of CVA were found in patients with Hb\u2003\u2264\u20039.0\u2003g\/dl, Ht\u2003\u2264\u200326.7% and sickle cell anaemia (SS) phenotype. Retinal vessel alteration (RVA) was identified only in patients aged 17\u2003years or older. Enalapril did not demonstrate ocular vessel amelioration after 12\u2010months of daily use.<\/jats:bold> <\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>  <jats:bold>The results indicate that lower Hb and Ht levels and SS phenotype are risk factors for CVA, and age over 17\u2003years may be risk factors for RVA in SCD patients.<\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.1600-0420.2005.00604.x","type":"journal-article","created":{"date-parts":[[2006,2,14]],"date-time":"2006-02-14T10:04:13Z","timestamp":1139911453000},"page":"234-241","source":"Crossref","is-referenced-by-count":12,"title":["Risk factors for conjunctival and retinal vessel alterations in sickle cell disease"],"prefix":"10.1111","volume":"84","author":[{"given":"Carmen S. 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